Smad6 negatively regulates interleukin 1-receptor–Toll-like receptor signaling through direct intera...
Smad6 negatively regulates interleukin 1-receptor–Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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Transforming growth factor-β1 (TGF-β1) is a potent cytokine with pleiotropic effects, including anti-inflammatory activity. Here we show that the signaling protein Smad6 bound to Pellino-1, an adaptor protein of mammalian interleukin 1 receptor (IL-1R)–associated kinase 1 (IRAK1), and thereby promoted TGF-β-mediated anti-inflammatory effects. Smad6...
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Full title
Smad6 negatively regulates interleukin 1-receptor–Toll-like receptor signaling through direct interaction with the adaptor Pellino-1
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TN_cdi_proquest_miscellaneous_851461504
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_851461504
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ISSN
1529-2908
E-ISSN
1529-2916,1365-2567
DOI
10.1038/ni1383
