The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
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Author / Creator
Rogaeva, Ekaterina , Meng, Yan , Lee, Joseph H , Gu, Yongjun , Kawarai, Toshitaka , Zou, Fanggeng , Katayama, Taiichi , Baldwin, Clinton T , Cheng, Rong , Hasegawa, Hiroshi , Chen, Fusheng , Shibata, Nobuto , Lunetta, Kathryn L , Pardossi-Piquard, Raphaelle , Bohm, Christopher , Wakutani, Yosuke , Cupples, L Adrienne , Cuenco, Karen T , Green, Robert C , Pinessi, Lorenzo , Rainero, Innocenzo , Sorbi, Sandro , Bruni, Amalia , Duara, Ranjan , Friedland, Robert P , Inzelberg, Rivka , Hampe, Wolfgang , Bujo, Hideaki , Song, You-Qiang , Andersen, Olav M , Willnow, Thomas E , Graff-Radford, Neill , Petersen, Ronald C , Dickson, Dennis , Der, Sandy D , Fraser, Paul E , Schmitt-Ulms, Gerold , Younkin, Steven , Mayeux, Richard , Farrer, Lindsay A and St George-Hyslop, Peter
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
The recycling of the amyloid precursor protein (APP) from the cell surface via the endocytic pathways plays a key role in the generation of amyloid β peptide (Aβ) in Alzheimer disease. We report here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease. These variants, which occur in at lea...
Alternative Titles
Full title
The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Authors, Artists and Contributors
Author / Creator
Meng, Yan
Lee, Joseph H
Gu, Yongjun
Kawarai, Toshitaka
Zou, Fanggeng
Katayama, Taiichi
Baldwin, Clinton T
Cheng, Rong
Hasegawa, Hiroshi
Chen, Fusheng
Shibata, Nobuto
Lunetta, Kathryn L
Pardossi-Piquard, Raphaelle
Bohm, Christopher
Wakutani, Yosuke
Cupples, L Adrienne
Cuenco, Karen T
Green, Robert C
Pinessi, Lorenzo
Rainero, Innocenzo
Sorbi, Sandro
Bruni, Amalia
Duara, Ranjan
Friedland, Robert P
Inzelberg, Rivka
Hampe, Wolfgang
Bujo, Hideaki
Song, You-Qiang
Andersen, Olav M
Willnow, Thomas E
Graff-Radford, Neill
Petersen, Ronald C
Dickson, Dennis
Der, Sandy D
Fraser, Paul E
Schmitt-Ulms, Gerold
Younkin, Steven
Mayeux, Richard
Farrer, Lindsay A
St George-Hyslop, Peter
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_proquest_miscellaneous_877597968
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_proquest_miscellaneous_877597968
Other Identifiers
ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng1943
