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PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154305

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation

About this item

Full title

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation

Publisher

London: Nature Publishing Group UK

Journal title

Cell death and differentiation, 2023-05, Vol.30 (5), p.1198-1210

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Elevated levels of PDLIM3 expression are frequently detected in sonic hedgehog (SHH) group of medulloblastoma (MB). However, the possible role of PDLIM3 in MB tumorigenesis is still unknown. Here, we found that PDLIM3 expression is necessary for hedgehog (Hh) pathway activation in MB cells. PDLIM3 is present in primary cilia of MB cells and fibrobl...

Alternative Titles

Full title

PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154305

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154305

Other Identifiers

ISSN

1350-9047

E-ISSN

1476-5403

DOI

10.1038/s41418-023-01131-2

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