PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation
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Author / Creator
Zhang, Jie , Yang, Yijun , Li, Xinhua , Li, Gen , Mizukami, Takuya , Liu, Yanli , Wang, Yuan , Xu, Guoqiang , Roder, Heinrich , Zhang, Li and Yang, Zeng-jie
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Elevated levels of PDLIM3 expression are frequently detected in sonic hedgehog (SHH) group of medulloblastoma (MB). However, the possible role of PDLIM3 in MB tumorigenesis is still unknown. Here, we found that PDLIM3 expression is necessary for hedgehog (Hh) pathway activation in MB cells. PDLIM3 is present in primary cilia of MB cells and fibrobl...
Alternative Titles
Full title
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154305
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10154305
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-023-01131-2
