Targeting TBK1 to overcome resistance to cancer immunotherapy
Targeting TBK1 to overcome resistance to cancer immunotherapy
About this item
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Author / Creator
Sun, Yi , Revach, Or-yam , Anderson, Seth , Kessler, Emily A. , Wolfe, Clara H. , Jenney, Anne , Mills, Caitlin E. , Robitschek, Emily J. , Davis, Thomas G. R. , Kim, Sarah , Fu, Amina , Ma, Xiang , Gwee, Jia , Tiwari, Payal , Du, Peter P. , Sindurakar, Princy , Tian, Jun , Mehta, Arnav , Schneider, Alexis M. , Yizhak, Keren , Sade-Feldman, Moshe , LaSalle, Thomas , Sharova, Tatyana , Xie, Hongyan , Liu, Shuming , Michaud, William A. , Saad-Beretta, Rodrigo , Yates, Kathleen B. , Iracheta-Vellve, Arvin , Spetz, Johan K. E. , Qin, Xingping , Sarosiek, Kristopher A. , Zhang, Gao , Kim, Jong Wook , Su, Mack Y. , Cicerchia, Angelina M. , Rasmussen, Martin Q. , Klempner, Samuel J. , Juric, Dejan , Pai, Sara I. , Miller, David M. , Giobbie-Hurder, Anita , Chen, Jonathan H. , Pelka, Karin , Frederick, Dennie T. , Stinson, Susanna , Ivanova, Elena , Aref, Amir R. , Paweletz, Cloud P. , Barbie, David A. , Sen, Debattama R. , Fisher, David E. , Corcoran, Ryan B. , Hacohen, Nir , Sorger, Peter K. , Flaherty, Keith T. , Boland, Genevieve M. , Manguso, Robert T. and Jenkins, Russell W.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Despite the success of PD-1 blockade in melanoma and other cancers, effective treatment strategies to overcome resistance to cancer immunotherapy are lacking
1
,
2
. Here we identify the innate immune kinase TANK-binding kinase 1 (
TBK1
)
3
as a candidate immune-evasion gene in a pooled genetic screen
4
. Using a suite...
Alternative Titles
Full title
Targeting TBK1 to overcome resistance to cancer immunotherapy
Authors, Artists and Contributors
Author / Creator
Revach, Or-yam
Anderson, Seth
Kessler, Emily A.
Wolfe, Clara H.
Jenney, Anne
Mills, Caitlin E.
Robitschek, Emily J.
Davis, Thomas G. R.
Kim, Sarah
Fu, Amina
Ma, Xiang
Gwee, Jia
Tiwari, Payal
Du, Peter P.
Sindurakar, Princy
Tian, Jun
Mehta, Arnav
Schneider, Alexis M.
Yizhak, Keren
Sade-Feldman, Moshe
LaSalle, Thomas
Sharova, Tatyana
Xie, Hongyan
Liu, Shuming
Michaud, William A.
Saad-Beretta, Rodrigo
Yates, Kathleen B.
Iracheta-Vellve, Arvin
Spetz, Johan K. E.
Qin, Xingping
Sarosiek, Kristopher A.
Zhang, Gao
Kim, Jong Wook
Su, Mack Y.
Cicerchia, Angelina M.
Rasmussen, Martin Q.
Klempner, Samuel J.
Juric, Dejan
Pai, Sara I.
Miller, David M.
Giobbie-Hurder, Anita
Chen, Jonathan H.
Pelka, Karin
Frederick, Dennie T.
Stinson, Susanna
Ivanova, Elena
Aref, Amir R.
Paweletz, Cloud P.
Barbie, David A.
Sen, Debattama R.
Fisher, David E.
Corcoran, Ryan B.
Hacohen, Nir
Sorger, Peter K.
Flaherty, Keith T.
Boland, Genevieve M.
Manguso, Robert T.
Jenkins, Russell W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10171827
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10171827
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-05704-6
