Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
About this item
Full title
Author / Creator
Hooftman, Alexander , Peace, Christian G. , Ryan, Dylan G. , Day, Emily A. , Yang, Ming , McGettrick, Anne F. , Yin, Maureen , Montano, Erica N. , Huo, Lihong , Toller-Kawahisa, Juliana E. , Zecchini, Vincent , Ryan, Tristram A. J. , Bolado-Carrancio, Alfonso , Casey, Alva M. , Prag, Hiran A. , Costa, Ana S. H. , De Los Santos, Gabriela , Ishimori, Mariko , Wallace, Daniel J. , Venuturupalli, Swamy , Nikitopoulou, Efterpi , Frizzell, Norma , Johansson, Cecilia , Von Kriegsheim, Alexander , Murphy, Michael P. , Jefferies, Caroline , Frezza, Christian and O’Neill, Luke A. J.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Metabolic rewiring underlies the effector functions of macrophages
1
–
3
, but the mechanisms involved remain incompletely defined. Here, using unbiased metabolomics and stable isotope-assisted tracing, we show that an inflammatory aspartate–argininosuccinate shunt is induced following lipopolysaccharide stimulation. The shunt, supporte...
Alternative Titles
Full title
Macrophage fumarate hydratase restrains mtRNA-mediated interferon production
Authors, Artists and Contributors
Author / Creator
Peace, Christian G.
Ryan, Dylan G.
Day, Emily A.
Yang, Ming
McGettrick, Anne F.
Yin, Maureen
Montano, Erica N.
Huo, Lihong
Toller-Kawahisa, Juliana E.
Zecchini, Vincent
Ryan, Tristram A. J.
Bolado-Carrancio, Alfonso
Casey, Alva M.
Prag, Hiran A.
Costa, Ana S. H.
De Los Santos, Gabriela
Ishimori, Mariko
Wallace, Daniel J.
Venuturupalli, Swamy
Nikitopoulou, Efterpi
Frizzell, Norma
Johansson, Cecilia
Von Kriegsheim, Alexander
Murphy, Michael P.
Jefferies, Caroline
Frezza, Christian
O’Neill, Luke A. J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10411300
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_10411300
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-023-05720-6
