Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical tri...
Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
About this item
Full title
Author / Creator
DIAN‐TU Study Team , for the DIAN‐TU Study Team , Wang, Guoqiao , Li, Yan , Xiong, Chengjie , Benzinger, Tammie L. S. , Gordon, Brian A. , Hassenstab, Jason , Aschenbrenner, Andrew J. , McDade, Eric , Clifford, David B. , Libre‐Guerra, Jorge J. , Shi, Xinyu , Mummery, Catherine J. , Dyck, Christopher H. , Lah, James J. , Honig, Lawrence S. , Day, Gregg , Ringman, John M. , Brooks, William S. , Fox, Nick C. , Suzuki, Kazushi , Levin, Johannes , Jucker, Mathias , Delmar, Paul , Bittner, Tobias and Bateman, Randall J.
Publisher
United States: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
INTRODUCTION
Increasing evidence suggests that amyloid reduction could serve as a plausible surrogate endpoint for clinical and cognitive efficacy. The double‐blind phase 3 DIAN‐TU‐001 trial tested clinical and cognitive declines with increasing doses of solanezumab or gantenerumab.
METHODS
We used latent class (LC) analysis on data from t...
Alternative Titles
Full title
Examining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease
Authors, Artists and Contributors
Author / Creator
for the DIAN‐TU Study Team
Wang, Guoqiao
Li, Yan
Xiong, Chengjie
Benzinger, Tammie L. S.
Gordon, Brian A.
Hassenstab, Jason
Aschenbrenner, Andrew J.
McDade, Eric
Clifford, David B.
Libre‐Guerra, Jorge J.
Shi, Xinyu
Mummery, Catherine J.
Dyck, Christopher H.
Lah, James J.
Honig, Lawrence S.
Day, Gregg
Ringman, John M.
Brooks, William S.
Fox, Nick C.
Suzuki, Kazushi
Levin, Johannes
Jucker, Mathias
Delmar, Paul
Bittner, Tobias
Bateman, Randall J.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11032558
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11032558
Other Identifiers
ISSN
1552-5260,1552-5279
E-ISSN
1552-5279
DOI
10.1002/alz.13735
