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Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates...

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1271751

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

About this item

Full title

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

Publisher

Chichester, UK: John Wiley & Sons, Ltd

Journal title

The EMBO journal, 2004-01, Vol.23 (2), p.386-395

Language

English

Formats

Publication information

Publisher

Chichester, UK: John Wiley & Sons, Ltd

More information

Scope and Contents

Contents

The two iron regulatory proteins IRP1 and IRP2 bind to transcripts of ferritin, transferrin receptor and other target genes to control the expression of iron metabolism proteins at the post‐transcriptional level. Here we compare the effects of genetic ablation of IRP1 to IRP2 in mice. IRP1−/− mice misregulate iron metabolism only in the kidney and...

Alternative Titles

Full title

Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1271751

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1271751

Other Identifiers

ISSN

0261-4189

E-ISSN

1460-2075

DOI

10.1038/sj.emboj.7600041

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