RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammat...
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies
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BioMed Central Ltd
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English
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BioMed Central Ltd
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INTRODUCTION: Rat adjuvant-induced arthritis (AIA) and collagen-induced arthritis (CIA) feature bone loss and systemic increases in TNFα, IL-1β, and receptor activator of NF-κB ligand (RANKL). Anti-IL-1 or anti-TNFα therapies consistently reduce inflammation in these models, but systemic bone loss often persists. RANKL inhibition consistently preve...
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Full title
RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3003514
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3003514
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ISSN
1478-6354
E-ISSN
1478-6354,1478-6362
DOI
10.1186/ar2879
