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Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab
Author / Creator:Lacey, David L. ; Boyle, William J. ; Simonet, W. Scott ; Kostenuik, Paul J. ; Dougall, William C. ; Sullivan, John K. ; Martin, Javier San ; Dansey, Roger
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2012-05, Vol.11 (5), p.401-419
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Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells
Author / Creator:Streicher, Carmen ; Heyny, Alexandra ; Andrukhova, Olena ; Haigl, Barbara ; Slavic, Svetlana ; Schüler, Christiane ; Kollmann, Karoline ; Kantner, Ingrid ; Sexl, Veronika ; Kleiter, Miriam ; Hofbauer, Lorenz C. ; Kostenuik, Paul J. ; Erben, Reinhold G.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2017-07, Vol.7 (1), p.6460-14, Article 6460
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Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects
Author / Creator:Yao, Yao ; Kauffmann, Frederic ; Maekawa, Shogo ; Sarment, Lea V. ; Sugai, James V. ; Schmiedeler, Caroline A. ; Doherty, Edward J. ; Holdsworth, Gill ; Kostenuik, Paul J. ; Giannobile, William V.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-10, Vol.10 (1), p.16217-16217, Article 16217
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Role of RANK Ligand and Denosumab, a Targeted RANK Ligand Inhibitor, in Bone Health and Osteoporosis: A Review of Preclinical and Clinical Data
Author / Creator:Dempster, David W., PhD ; Lambing, Cheryl L., MD ; Kostenuik, Paul J., PhD ; Grauer, Andreas, MD
Publisher:United States: EM Inc USA
Journal title:Clinical therapeutics, 2012-03, Vol.34 (3), p.521-536
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Sclerostin-Neutralizing Antibody Enhances Bone Regeneration Around Oral Implants
Author / Creator:Yu, Shan Huey ; Hao, Jie ; Fretwurst, Tobias ; Liu, Min ; Kostenuik, Paul ; Giannobile, William V. ; Jin, Qiming
Publisher:United States: Mary Ann Liebert, Inc., publishers
Journal title:Tissue engineering. Part A, 2018-11, Vol.24 (21-22), p.1672-1679
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Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
Author / Creator:Canon, Jude R. ; Roudier, Martine ; Bryant, Rebecca ; Morony, Sean ; Stolina, Marina ; Kostenuik, Paul J. ; Dougall, William C.
Publisher:Dordrecht: Springer Netherlands
Journal title:Clinical & experimental metastasis, 2008-04, Vol.25 (2), p.119-129
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Proximal Femur Responses to Sequential Therapy With Abaloparatide Followed by Alendronate in Postmenopausal Women With Osteoporosis by 3D Modeling of Hip Dual‐Energy X‐Ray Absorptiometry (DXA)
Author / Creator:Winzenrieth, Renaud ; Kostenuik, Paul ; Boxberger, John ; Wang, Yamei ; Humbert, Ludovic
Publisher:Hoboken, USA: John Wiley & Sons, Inc
Journal title:JBMR plus, 2022-04, Vol.6 (4), p.e10612-n/a
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Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction
Author / Creator:Slavic, Svetlana ; Andrukhova, Olena ; Ford, Kristopher ; Handschuh, Stephan ; Latic, Nejla ; Reichart, Ursula ; Sasgary, Soleman ; Bergow, Claudia ; Hofbauer, Lorenz C. ; Kostenuik, Paul J. ; Erben, Reinhold G.
Publisher:Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title:Journal of molecular medicine (Berlin, Germany), 2018-06, Vol.96 (6), p.559-573
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Influence of Fatigue Loading and Bone Turnover on Bone Strength and Pattern of Experimental Fractures of the Tibia in Mice
Author / Creator:Bonnet, Nicolas ; Gerbaix, Maude ; Ominsky, Michael ; Ammann, Patrick ; Kostenuik, Paul J. ; Ferrari, Serge L.
Publisher:New York: Springer US
Journal title:Calcified tissue international, 2016-07, Vol.99 (1), p.99-109
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Local Delivery of Recombinant Osteoprotegerin Enhances Postorthodontic Tooth Stability
Author / Creator:Hudson, James Bradley ; Hatch, Nan ; Hayami, Takayuki ; Shin, Jae M. ; Stolina, Marina ; Kostenuik, Paul J. ; Kapila, Sunil
Publisher:New York: Springer-Verlag
Journal title:Calcified tissue international, 2012-04, Vol.90 (4), p.330-342
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Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes
Author / Creator:Beck, Felicitas ; Hartmann, Eliza S ; Koehler, Miriam I ; Redeker, Julia I ; Schluessel, Sabine ; Schmitt, Baerbel ; Fottner, Andreas ; Unger, Marina ; van Griensven, Martijn ; Michael, Jan ; Summer, Burkhard ; Kunzelmann, Karl-Heinz ; Beutner, Rene ; Scharnweber, Dieter ; Kostenuik, Paul J ; Mayer-Wagner, Susanne
Publisher:Switzerland: MDPI AG
Journal title:International journal of molecular sciences, 2019-02, Vol.20 (5), p.1002
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Denosumab Use in Rats: Letter to the Editor
Author / Creator:Kostenuik, Paul
Publisher:Los Angeles, CA: SAGE Publications
Journal title:The American journal of sports medicine, 2023-02, Vol.51 (2), p.NP8-NP8
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Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases
Author / Creator:Morrissey, Colm ; Kostenuik, Paul L ; Brown, Lisha G ; Vessella, Robert L ; Corey, Eva
Publisher:England: BioMed Central Ltd
Journal title:BMC cancer, 2007-08, Vol.7 (1), p.148-148, Article 148
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Osteoprotegerin A Physiological and Pharmacological Inhibitor of Bone Resorption
Author / Creator:Kostenuik, P J ; Shalhoub, V
Publisher:United Arab Emirates: Bentham Science Publishers Ltd
Journal title:Current pharmaceutical design, 2001-05, Vol.7 (8), p.613-635
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RANK Is the Intrinsic Hematopoietic Cell Surface Receptor That Controls Osteoclastogenesis and Regulation of Bone Mass and Calcium Metabolism
Author / Creator:Li, Ji ; Sarosi, Ildiko ; Yan, Xiao-Qiang ; Morony, Sean ; Capparelli, Casey ; Tan, Hong-Lin ; McCabe, Susan ; Elliott, Robin ; Scully, Sheila ; Van, Gwyneth ; Kaufman, Stephen ; Juan, Shao-Chieh ; Sun, Yu ; Tarpley, John ; Martin, Laura ; Christensen, Kathleen ; McCabe, James ; Kostenuik, Paul ; Hsu, Hailing ; Fletcher, Frederick ; Dunstan, Colin R. ; Lacey, David L. ; Boyle, William J.
Publisher:United States: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1566-1571
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Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis
Author / Creator:Stolina, Marina ; Bolon, Brad ; Middleton, Scot ; Dwyer, Denise ; Brown, Heather ; Duryea, Diane ; Zhu, Li ; Rohner, Alison ; Pretorius, James ; Kostenuik, Paul ; Feige, Ulrich ; Zack, Debra
Publisher:Boston: Boston : Springer US
Journal title:Journal of clinical immunology, 2009-03, Vol.29 (2), p.158-174
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Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis
Author / Creator:Canon, Jude R. ; Roudier, Martine ; Bryant, Rebecca ; Morony, Sean ; Stolina, Marina ; Kostenuik, Paul J. ; Dougall, William C.
Journal title:Clinical & experimental metastasis, 2008-04, Vol.25 (2), p.119-129
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Healing sequelae following tooth extraction and dental implant placement in an aged, ovariectomy model
Author / Creator:Latimer, Jessica M ; Maekawa, Shogo ; Shiba, Takahiko ; Fretwurst, Tobias ; Chen, Michael ; Larsson, Lena ; Sugai, James V ; Kostenuik, Paul ; Mitlak, Bruce ; Lanske, Beate ; Giannobile, William V
Publisher:England
Journal title:JBMR plus, 2024-10, Vol.8 (10), p.ziae113
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Integrin αvβ3 as a PET Imaging Biomarker for Osteoclast Number in Mouse Models of Negative and Positive Osteoclast Regulation
Author / Creator:Zheleznyak, Alexander ; Wadas, Thaddeus J. ; Sherman, Christopher D. ; Wilson, Jessica M. ; Kostenuik, Paul J. ; Weilbaecher, Katherine N. ; Anderson, Carolyn J.
Publisher:New York: Springer-Verlag
Journal title:Molecular imaging and biology, 2012-08, Vol.14 (4), p.500-508
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RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies
Author / Creator:Stolina, Marina ; Schett, Georg ; Dwyer, Denise ; Vonderfecht, Steven ; Middleton, Scot ; Duryea, Diane ; Pacheco, Efrain ; Van, Gwyneth ; Bolon, Brad ; Feige, Ulrich ; Zack, Debra ; Kostenuik, Paul
Publisher:BioMed Central Ltd
Journal title:Arthritis research & therapy, 2009-01, Vol.11 (6), p.R187-R187, Article R187
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Bench to bedside: elucidation of the OPG–RANK–RANKL pathway and the development of denosumab

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Estrogen Regulates Bone Turnover by Targeting RANKL Expression in Bone Lining Cells

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Sclerostin antibody stimulates periodontal regeneration in large alveolar bone defects

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Role of RANK Ligand and Denosumab, a Targeted RANK Ligand Inhibitor, in Bone Health and Osteoporosis: A Review of Preclinical and Clinical Data

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Sclerostin-Neutralizing Antibody Enhances Bone Regeneration Around Oral Implants

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Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis

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Proximal Femur Responses to Sequential Therapy With Abaloparatide Followed by Alendronate in Postmenopausal Women With Osteoporosis by 3D Modeling of Hip Dual‐Energy X‐Ray Absorptiometry (DXA)

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Selective inhibition of receptor activator of NF-κB ligand (RANKL) in hematopoietic cells improves outcome after experimental myocardial infarction

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Influence of Fatigue Loading and Bone Turnover on Bone Strength and Pattern of Experimental Fractures of the Tibia in Mice

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Local Delivery of Recombinant Osteoprotegerin Enhances Postorthodontic Tooth Stability

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Immobilization of Denosumab on Titanium Affects Osteoclastogenesis of Human Peripheral Blood Monocytes

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Denosumab Use in Rats: Letter to the Editor

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Host-derived RANKL is responsible for osteolysis in a C4-2 human prostate cancer xenograft model of experimental bone metastases

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Osteoprotegerin A Physiological and Pharmacological Inhibitor of Bone Resorption

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RANK Is the Intrinsic Hematopoietic Cell Surface Receptor That Controls Osteoclastogenesis and Regulation of Bone Mass and Calcium Metabolism

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Evolving Systemic and Local Biomarker Milieu at Different Stages of Disease Progression in Rat Adjuvant-Induced Arthritis

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Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasis

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Healing sequelae following tooth extraction and dental implant placement in an aged, ovariectomy model

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Integrin αvβ3 as a PET Imaging Biomarker for Osteoclast Number in Mouse Models of Negative and Positive Osteoclast Regulation

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RANKL inhibition by osteoprotegerin prevents bone loss without affecting local or systemic inflammation parameters in two rat arthritis models: comparison with anti-TNFα or anti-IL-1 therapies

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