T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer bu...
T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
About this item
Full title
Author / Creator
Parkhurst, Maria R , Yang, James C , Langan, Russell C , Dudley, Mark E , Nathan, Debbie-Ann N , Feldman, Steven A , Davis, Jeremy L , Morgan, Richard A , Merino, Maria J , Sherry, Richard M , Hughes, Marybeth S , Kammula, Udai S , Phan, Giao Q , Lim, Ramona M , Wank, Stephen A , Restifo, Nicholas P , Robbins, Paul F , Laurencot, Carolyn M and Rosenberg, Steven A
Publisher
United States: Elsevier Inc
Journal title
Language
English
Formats
Publication information
Publisher
United States: Elsevier Inc
Subjects
More information
Scope and Contents
Contents
Autologous T lymphocytes genetically engineered to express a murine T cell receptor (TCR) against human carcinoembryonic antigen (CEA) were administered to three patients with metastatic colorectal cancer refractory to standard treatments. All patients experienced profound decreases in serum CEA levels (74–99%), and one patient had an objective reg...
Alternative Titles
Full title
T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis
Authors, Artists and Contributors
Author / Creator
Yang, James C
Langan, Russell C
Dudley, Mark E
Nathan, Debbie-Ann N
Feldman, Steven A
Davis, Jeremy L
Morgan, Richard A
Merino, Maria J
Sherry, Richard M
Hughes, Marybeth S
Kammula, Udai S
Phan, Giao Q
Lim, Ramona M
Wank, Stephen A
Restifo, Nicholas P
Robbins, Paul F
Laurencot, Carolyn M
Rosenberg, Steven A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3048186
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3048186
Other Identifiers
ISSN
1525-0016
E-ISSN
1525-0024
DOI
10.1038/mt.2010.272
