A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
Journal title
Language
English
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Publisher
Chichester, UK: John Wiley & Sons, Ltd
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Scope and Contents
Contents
The G protein‐coupled receptor (GPCR) Proteolysis Site (GPS) of cell‐adhesion GPCRs and polycystic kidney disease (PKD) proteins constitutes a highly conserved autoproteolysis sequence, but its catalytic mechanism remains unknown. Here, we show that unexpectedly the ∼40‐residue GPS motif represents an integral part of a much larger ∼320‐residue dom...
Alternative Titles
Full title
A novel evolutionarily conserved domain of cell-adhesion GPCRs mediates autoproteolysis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321182
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3321182
Other Identifiers
ISSN
0261-4189
E-ISSN
1460-2075
DOI
10.1038/emboj.2012.26
