NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Franzoso and colleagues show that NF-κB protects cells from nutrient-starvation-induced necrosis by upregulating mitochondrial respiration through increased p53-dependent expression of the SCO2 enzyme. Conversely, inhibition of NF-κB results in increased aerobic glycolysis, known as the Warburg effect, thus promoting oncogenic transformation, and a...
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Full title
NF-κB controls energy homeostasis and metabolic adaptation by upregulating mitochondrial respiration
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3462316
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3462316
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ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2324
