MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
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Author / Creator
Jessen, Walter J , Miller, Shyra J , Jousma, Edwin , Wu, Jianqiang , Rizvi, Tilat A , Brundage, Meghan E , Eaves, David , Widemann, Brigitte , Kim, Mi-Ok , Dombi, Eva , Sabo, Jessica , Hardiman Dudley, Atira , Niwa-Kawakita, Michiko , Page, Grier P , Giovannini, Marco , Aronow, Bruce J , Cripe, Timothy P and Ratner, Nancy
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
Neurofibromatosis type 1 (NF1) patients develop benign neurofibromas and malignant peripheral nerve sheath tumors (MPNST). These incurable peripheral nerve tumors result from loss of NF1 tumor suppressor gene function, causing hyperactive Ras signaling. Activated Ras controls numerous downstream effectors, but specific pathways mediating the effect...
Alternative Titles
Full title
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3533264
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3533264
Other Identifiers
ISSN
0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI60578
