Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome...
Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Lysosome is a key subceilular organelle in the execution of the autophagic process and at present little is known whether lysosomal function is controlled in the process of autophagy. In this study, we first found that suppression of mammalian target of rapamycin （mTOR） activity by starvation or two mTOR catalytic inhibitors （PP242 and To- rinl）, b...
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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3616426
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3616426
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ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2013.11
