Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal...
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
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New York: Nature Publishing Group US
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English
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New York: Nature Publishing Group US
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In an evolutionarily conserved signaling pathway, 'soluble' adenylyl cyclases (sACs) synthesize the ubiquitous second messenger cyclic adenosine 3′,5′-monophosphate (cAMP) in response to bicarbonate and calcium signals. Here, we present crystal structures of a cyanobacterial sAC enzyme in complex with ATP analogs, calcium and bicarbonate, which rep...
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Full title
Bicarbonate activation of adenylyl cyclase via promotion of catalytic active site closure and metal recruitment
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3644947
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3644947
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ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/nsmb880
