Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
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Author / Creator
Shalek, Alex K. , Satija, Rahul , Adiconis, Xian , Gertner, Rona S. , Gaublomme, Jellert T. , Raychowdhury, Raktima , Schwartz, Schraga , Yosef, Nir , Malboeuf, Christine , Lu, Diana , Trombetta, John J. , Gennert, Dave , Gnirke, Andreas , Goren, Alon , Hacohen, Nir , Levin, Joshua Z. , Park, Hongkun and Regev, Aviv
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Single-cell RNA sequencing is used to investigate the transcriptional response of 18 mouse bone-marrow-derived dendritic cells after lipopolysaccharide stimulation; many highly expressed genes, such as key immune genes and cytokines, show bimodal variation in both transcript abundance and splicing patterns. This variation reflects differences in bo...
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Full title
Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3683364
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3683364
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature12172
