Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The DNA-damage response (DDR) arrests cell-cycle progression until damage is removed. DNA-damage-induced cellular senescence is associated with persistent DDR. The molecular bases that distinguish transient from persistent DDR are unknown. Here we show that a large fraction of exogenously induced persistent DDR markers is associated with telomeric...
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Full title
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3717580
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3717580
Other Identifiers
ISSN
1465-7392
E-ISSN
1476-4679
DOI
10.1038/ncb2466
