RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
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Author / Creator
Su, Fei , Viros, Amaya , Milagre, Carla , Trunzer, Kerstin , Bollag, Gideon , Spleiss, Olivia , Reis-Filho, Jorge S , Kong, Xiangju , Koya, Richard C , Flaherty, Keith T , Chapman, Paul B , Kim, Min Jung , Hayward, Robert , Martin, Matthew , Yang, Hong , Wang, Qiongqing , Hilton, Holly , Hang, Julie S , Noe, Johannes , Lambros, Maryou , Geyer, Felipe , Dhomen, Nathalie , Niculescu-Duvaz, Dan , Niculescu-Duvaz, Ion , Zambon, Alfonso , Preece, Natasha , Robert, Lídia , Otte, Nicholas J , Mok, Stephen , Kee, Damien , Ma, Yan , Zhang, Chao , Habets, Gaston , Burton, Elizabeth A , Wong, Bernice , Nguyen, Hoa , Kockx, Mark , Andries, Luc , Lestini, Brian , Nolop, Keith B , Lee, Richard J , Joe, Andrew K , Troy, James L , Gonzalez, Rene , Hutson, Thomas E , Puzanov, Igor , Chmielowski, Bartosz , Springer, Caroline J , McArthur, Grant A , Sosman, Jeffrey A , Lo, Roger S , Ribas, Antoni and Marais, Richard
Publisher
Waltham, MA: Massachusetts Medical Society
Journal title
Language
English
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Publication information
Publisher
Waltham, MA: Massachusetts Medical Society
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Scope and Contents
Contents
Patients with melanoma who are treated with a BRAF inhibitor have a high incidence of keratoacanthomas. Most of the tumors have oncogenic mutations in HRAS that probably preceded the use of the BRAF inhibitor. In animal models, second tumors are blocked when a MEK inhibitor is added to the BRAF inhibitor.
The t→a transversion at position 1799 of...
Alternative Titles
Full title
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
Authors, Artists and Contributors
Author / Creator
Viros, Amaya
Milagre, Carla
Trunzer, Kerstin
Bollag, Gideon
Spleiss, Olivia
Reis-Filho, Jorge S
Kong, Xiangju
Koya, Richard C
Flaherty, Keith T
Chapman, Paul B
Kim, Min Jung
Hayward, Robert
Martin, Matthew
Yang, Hong
Wang, Qiongqing
Hilton, Holly
Hang, Julie S
Noe, Johannes
Lambros, Maryou
Geyer, Felipe
Dhomen, Nathalie
Niculescu-Duvaz, Dan
Niculescu-Duvaz, Ion
Zambon, Alfonso
Preece, Natasha
Robert, Lídia
Otte, Nicholas J
Mok, Stephen
Kee, Damien
Ma, Yan
Zhang, Chao
Habets, Gaston
Burton, Elizabeth A
Wong, Bernice
Nguyen, Hoa
Kockx, Mark
Andries, Luc
Lestini, Brian
Nolop, Keith B
Lee, Richard J
Joe, Andrew K
Troy, James L
Gonzalez, Rene
Hutson, Thomas E
Puzanov, Igor
Chmielowski, Bartosz
Springer, Caroline J
McArthur, Grant A
Sosman, Jeffrey A
Lo, Roger S
Ribas, Antoni
Marais, Richard
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3724537
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_3724537
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1105358
