Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxire...
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
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United States: National Academy of Sciences
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Language
English
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United States: National Academy of Sciences
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Local levels of active thyroid hormone (3,3′,5-triiodothyronine) are controlled by the action of activating and inactivating iodothyronine deiodinase enzymes. Deiodinases are selenocysteine-dependent membrane proteins catalyzing the reductive elimination of iodide from iodothyronines through a poorly understood mechanism. We solved the crystal stru...
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Full title
Crystal structure of mammalian selenocysteine-dependent iodothyronine deiodinase suggests a peroxiredoxin-like catalytic mechanism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4115520
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4115520
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1323873111
