The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiq...
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes
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Author / Creator
Wang, Hong-Mei , Xu, Yun-Fei , Ning, Shang-Lei , Yang, Du-Xiao , Li, Yi , Du, Yu-Jie , Yang, Fan , Zhang, Ya , Liang, Nan , Yao, Wei , Zhang, Ling-Li , Gu, Li-Chuan , Gao, Cheng-Jiang , Pang, Qi , Chen, Yu-Xin , Xiao, Kun-Hong , Ma, Rong , Yu, Xiao and Sun, Jin-Peng
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The tyrosine phosphorylation barcode encoded in C-terminus of HER2 and its ubiquitination regulate diverse HER2 functions. PTPN18 was reported as a HER2 phosphatase; however, the exact mechanism by which it defines HER2 signaling is not fully understood. Here, we demonstrate that PTPN18 regulates HER2-mediated cellular functions through defining bo...
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Full title
The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4152746
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4152746
Other Identifiers
ISSN
1001-0602
E-ISSN
1748-7838
DOI
10.1038/cr.2014.99
