Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of mult...
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
About this item
Full title
Author / Creator
Jiang, Mali , Wang, Jiawei , Fu, Jinrong , Du, Lin , Jeong, Hyunkyung , West, Tim , Xiang, Lan , Peng, Qi , Hou, Zhipeng , Cai, Huan , Seredenina, Tamara , Arbez, Nicolas , Zhu, Shanshan , Sommers, Katherine , Qian, Jennifer , Zhang, Jiangyang , Mori, Susumu , Yang, X William , Tamashiro, Kellie L K , Aja, Susan , Moran, Timothy H , Luthi-Carter, Ruth , Martin, Bronwen , Maudsley, Stuart , Mattson, Mark P , Cichewicz, Robert H , Ross, Christopher A , Holtzman, David M , Krainc, Dimitri and Duan, Wenzhen
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Huntington's disease is a neurodegenerative disease caused by the accumulation of mutant htt protein. Now, two groups led by Dimitri Krainc and Wenzhen Duan report that mutant htt binds and inactivates the deacetylase enzyme SIRT1 and that SIRT1 overexpression is protective in Huntington's disease mouse models.
Huntington's disease is a fatal ne...
Alternative Titles
Full title
Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets
Authors, Artists and Contributors
Author / Creator
Wang, Jiawei
Fu, Jinrong
Du, Lin
Jeong, Hyunkyung
West, Tim
Xiang, Lan
Peng, Qi
Hou, Zhipeng
Cai, Huan
Seredenina, Tamara
Arbez, Nicolas
Zhu, Shanshan
Sommers, Katherine
Qian, Jennifer
Zhang, Jiangyang
Mori, Susumu
Yang, X William
Tamashiro, Kellie L K
Aja, Susan
Moran, Timothy H
Luthi-Carter, Ruth
Martin, Bronwen
Maudsley, Stuart
Mattson, Mark P
Cichewicz, Robert H
Ross, Christopher A
Holtzman, David M
Krainc, Dimitri
Duan, Wenzhen
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4551453
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4551453
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.2558
