Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
About this item
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Author / Creator
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
Journal title
Language
English
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Publication information
Publisher
Berlin/Heidelberg: Springer Berlin Heidelberg
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Scope and Contents
Contents
Amyotrophic lateral sclerosis is characterized by progressive loss of motor neurons in the brain and spinal cord. Mutations in several genes, including FUS, TDP43, Matrin 3, hnRNPA2 and other RNA-binding proteins, have been linked to ALS pathology. Recently, Pur-alpha, a DNA/RNA-binding protein was found to bind to C9orf72 repeat expansions and cou...
Alternative Titles
Full title
Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4791193
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4791193
Other Identifiers
ISSN
0001-6322
E-ISSN
1432-0533
DOI
10.1007/s00401-015-1530-0
