sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
About this item
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Author / Creator
Kaur, Amanpreet , Webster, Marie R. , Marchbank, Katie , Behera, Reeti , Ndoye, Abibatou , Kugel, Curtis H. , Dang, Vanessa M. , Appleton, Jessica , O’Connell, Michael P. , Cheng, Phil , Valiga, Alexander A. , Morissette, Rachel , McDonnell, Nazli B. , Ferrucci, Luigi , Kossenkov, Andrew V. , Meeth, Katrina , Tang, Hsin-Yao , Yin, Xiangfan , Wood, William H. , Lehrmann, Elin , Becker, Kevin G. , Flaherty, Keith T. , Frederick, Dennie T. , Wargo, Jennifer A. , Cooper, Zachary A. , Tetzlaff, Michael T. , Hudgens, Courtney , Aird, Katherine M. , Zhang, Rugang , Xu, Xiaowei , Liu, Qin , Bartlett, Edmund , Karakousis, Giorgos , Eroglu, Zeynep , Lo, Roger S. , Chan, Matthew , Menzies, Alexander M. , Long, Georgina V. , Johnson, Douglas B. , Sosman, Jeffrey , Schilling, Bastian , Schadendorf, Dirk , Speicher, David W. , Bosenberg, Marcus , Ribas, Antoni and Weeraratna, Ashani T.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Aged fibroblasts release a Wnt antagonist, sFRP2, which drives a signalling cascade in melanoma cells, leading to increased metastasis and reduced effectiveness of targeted therapy.
Age-related effects on cancer progression
The incidence of cancer increases with age, leading Ashani Weeraratna and colleagues to consider the role that the agein...
Alternative Titles
Full title
sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Authors, Artists and Contributors
Author / Creator
Webster, Marie R.
Marchbank, Katie
Behera, Reeti
Ndoye, Abibatou
Kugel, Curtis H.
Dang, Vanessa M.
Appleton, Jessica
O’Connell, Michael P.
Cheng, Phil
Valiga, Alexander A.
Morissette, Rachel
McDonnell, Nazli B.
Ferrucci, Luigi
Kossenkov, Andrew V.
Meeth, Katrina
Tang, Hsin-Yao
Yin, Xiangfan
Wood, William H.
Lehrmann, Elin
Becker, Kevin G.
Flaherty, Keith T.
Frederick, Dennie T.
Wargo, Jennifer A.
Cooper, Zachary A.
Tetzlaff, Michael T.
Hudgens, Courtney
Aird, Katherine M.
Zhang, Rugang
Xu, Xiaowei
Liu, Qin
Bartlett, Edmund
Karakousis, Giorgos
Eroglu, Zeynep
Lo, Roger S.
Chan, Matthew
Menzies, Alexander M.
Long, Georgina V.
Johnson, Douglas B.
Sosman, Jeffrey
Schilling, Bastian
Schadendorf, Dirk
Speicher, David W.
Bosenberg, Marcus
Ribas, Antoni
Weeraratna, Ashani T.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4833579
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4833579
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature17392
