Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive...
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
Soumya Raychaudhuri and colleagues present a detailed analysis of the association between the HLA region and type 1 diabetes risk. They find that variants at three amino acid positions in HLA-DQβ1 and HLA-DRβ1 account for a large fraction of the association signal, acting through a combination of additive and interaction effects.
Variation in th...
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Full title
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4930791
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_4930791
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ISSN
1061-4036
E-ISSN
1546-1718
DOI
10.1038/ng.3353
