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ArticlesPeer ReviewedFull Text
Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy
Author / Creator:Chowell, Diego ; Krishna, Chirag ; Pierini, Federica ; Makarov, Vladimir ; Rizvi, Naiyer A. ; Kuo, Fengshen ; Morris, Luc G. T. ; Riaz, Nadeem ; Lenz, Tobias L. ; Chan, Timothy A.
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2019-11, Vol.25 (11), p.1715-1720
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COMPUTATIONAL PREDICTION OF MHC II-ANTIGEN BINDING SUPPORTS DIVERGENT ALLELE ADVANTAGE AND EXPLAINS TRANS-SPECIES POLYMORPHISM
Author / Creator:Lenz, Tobias L.
Publisher:Malden, USA: Blackwell Publishing Inc
Journal title:Evolution, 2011-08, Vol.65 (8), p.2380-2390
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ArticlesPeer ReviewedFull Text
Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations
Author / Creator:Eizaguirre, Christophe ; Lenz, Tobias L. ; Kalbe, Martin ; Milinski, Manfred
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2012-01, Vol.3 (1), p.621-621, Article 621
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HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation
Author / Creator:Arora, Jatin ; Pierini, Federica ; McLaren, Paul J ; Carrington, Mary ; Fellay, Jacques ; Lenz, Tobias L
Publisher:Oxford: Oxford University Press
Journal title:Molecular biology and evolution, 2020-03, Vol.37 (3), p.639-650
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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk
Author / Creator:Hu, Xinli ; Deutsch, Aaron J ; Lenz, Tobias L ; Onengut-Gumuscu, Suna ; Han, Buhm ; Chen, Wei-Min ; Howson, Joanna M M ; Todd, John A ; de Bakker, Paul I W ; Rich, Stephen S ; Raychaudhuri, Soumya
Publisher:New York: Nature Publishing Group US
Journal title:Nature genetics, 2015-08, Vol.47 (8), p.898-905
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Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations
Author / Creator:Manczinger, Máté ; Boross, Gábor ; Kemény, Lajos ; Müller, Viktor ; Lenz, Tobias L. ; Papp, Balázs ; Pál, Csaba
Publisher:United States: Public Library of Science
Journal title:PLoS biology, 2019-01, Vol.17 (1), p.e3000131-e3000131
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Genomics of Divergence along a Continuum of Parapatric Population Differentiation
Author / Creator:Feulner, Philine G. D. ; Chain, Frédéric J. J. ; Panchal, Mahesh ; Huang, Yun ; Eizaguirre, Christophe ; Kalbe, Martin ; Lenz, Tobias L. ; Samonte, Irene E. ; Stoll, Monika ; Bornberg-Bauer, Erich ; Reusch, Thorsten B. H. ; Milinski, Manfred
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2015-02, Vol.11 (2), p.e1004966-e1004966
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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection
Author / Creator:Lenz, Tobias L ; Spirin, Victor ; Jordan, Daniel M ; Sunyaev, Shamil R
Publisher:Oxford: Oxford University Press
Journal title:Molecular biology and evolution, 2016-10, Vol.33 (10), p.2555-2564
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Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease
Author / Creator:Sakaue, Saori ; Gurajala, Saisriram ; Curtis, Michelle ; Luo, Yang ; Choi, Wanson ; Ishigaki, Kazuyoshi ; Kang, Joyce B. ; Rumker, Laurie ; Deutsch, Aaron J. ; Schönherr, Sebastian ; Forer, Lukas ; LeFaive, Jonathon ; Fuchsberger, Christian ; Han, Buhm ; Lenz, Tobias L. ; de Bakker, Paul I. W. ; Okada, Yukinori ; Smith, Albert V. ; Raychaudhuri, Soumya
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2023-09, Vol.18 (9), p.2625-2641
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Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans
Author / Creator:Krause-Kyora, Ben ; Nutsua, Marcel ; Boehme, Lisa ; Pierini, Federica ; Pedersen, Dorthe Dangvard ; Kornell, Sabin-Christin ; Drichel, Dmitriy ; Bonazzi, Marion ; Möbus, Lena ; Tarp, Peter ; Susat, Julian ; Bosse, Esther ; Willburger, Beatrix ; Schmidt, Alexander H. ; Sauter, Jürgen ; Franke, Andre ; Wittig, Michael ; Caliebe, Amke ; Nothnagel, Michael ; Schreiber, Stefan ; Boldsen, Jesper L. ; Lenz, Tobias L. ; Nebel, Almut
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2018-05, Vol.9 (1), p.1569-11, Article 1569
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Admixture as a source for HLA variation in Neolithic European farming communities
Author / Creator:da Silva, Nicolas Antonio ; Özer, Onur ; Haller-Caskie, Magdalena ; Chen, Yan-Rong ; Kolbe, Daniel ; Schade-Lindig, Sabine ; Wahl, Joachim ; Berszin, Carola ; Francken, Michael ; Görner, Irina ; Schierhold, Kerstin ; Pechtl, Joachim ; Grupe, Gisela ; Rinne, Christoph ; Müller, Johannes ; Lenz, Tobias L. ; Nebel, Almut ; Krause-Kyora, Ben
Publisher:England: BioMed Central Ltd
Journal title:Genome Biology, 2025-02, Vol.26 (1), p.43-43, Article 43
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Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals
Author / Creator:Tebbe, Jonas ; Ottensmann, Meinolf ; Havenstein, Katja ; Efstratiou, Artemis ; Lenz, Tobias L. ; Caspers, Barbara A. ; Forcada, Jaume ; Tiedemann, Ralph ; Hoffman, Joseph I.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2022-10, Vol.12 (1), p.17933-17933, Article 17933
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Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data
Author / Creator:ElAbd, Hesham ; Degenhardt, Frauke ; Koudelka, Tomas ; Kamps, Ann-Kristin ; Tholey, Andreas ; Bacher, Petra ; Lenz, Tobias L. ; Franke, Andre ; Wendorff, Mareike
Publisher:London: BioMed Central Ltd
Journal title:BMC bioinformatics, 2021-08, Vol.22 (1), p.1-405, Article 405
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Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection
Author / Creator:Pierini, Federica ; Lenz, Tobias L
Publisher:Oxford: Oxford University Press
Journal title:Molecular biology and evolution, 2018-09, Vol.35 (9), p.2145-2158
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Extensive Copy-Number Variation of Young Genes across Stickleback Populations
Author / Creator:Chain, Frédéric J. J. ; Feulner, Philine G. D. ; Panchal, Mahesh ; Eizaguirre, Christophe ; Samonte, Irene E. ; Kalbe, Martin ; Lenz, Tobias L. ; Stoll, Monika ; Bornberg-Bauer, Erich ; Milinski, Manfred ; Reusch, Thorsten B. H.
Publisher:United States: Public Library of Science
Journal title:PLoS genetics, 2014-12, Vol.10 (12), p.e1004830-e1004830
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Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations
Author / Creator:Pierini, Federica ; Nutsua, Marcel ; Böhme, Lisa ; Özer, Onur ; Bonczarowska, Joanna ; Susat, Julian ; Franke, Andre ; Nebel, Almut ; Krause-Kyora, Ben ; Lenz, Tobias L.
Publisher:London: Nature Publishing Group UK
Journal title:Scientific reports, 2020-04, Vol.10 (1), p.7339-7339, Article 7339
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Evaluation of Genetic Diversity and Parasite-Mediated Selection of MHC Class I Genes in Emberiza godlewskii (Passeriformes: Emberizidae)
Author / Creator:Huang, Wei ; Wang, Xinyi ; Liu, Boye ; Lenz, Tobias L. ; Peng, Yangyang ; Dong, Lu ; Zhang, Yanyun
Publisher:Basel: MDPI AG
Journal title:Diversity (Basel), 2022-11, Vol.14 (11), p.925
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Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus)
Author / Creator:Lenz, Tobias L ; Wells, Konstans ; Pfeiffer, Martin ; Sommer, Simone
Publisher:England: BioMed Central Ltd
Journal title:BMC evolutionary biology, 2009-11, Vol.9 (1), p.269-269, Article 269
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Uterine selection for immunocompetent offspring
Author / Creator:Lenz, Tobias L.
Publisher:United States: National Acad Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2011-07, Vol.108 (27), p.E253-E253; author reply E254
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Adaptive value of novel MHC immune gene variants
Author / Creator:Lenz, Tobias L.
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2018-02, Vol.115 (7), p.1414-1416
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Showing 1 to 20 of 54 results

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Evolutionary divergence of HLA class I genotype impacts efficacy of cancer immunotherapy

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COMPUTATIONAL PREDICTION OF MHC II-ANTIGEN BINDING SUPPORTS DIVERGENT ALLELE ADVANTAGE AND EXPLAINS TRANS-SPECIES POLYMORPHISM

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Rapid and adaptive evolution of MHC genes under parasite selection in experimental vertebrate populations

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HLA Heterozygote Advantage against HIV-1 Is Driven by Quantitative and Qualitative Differences in HLA Allele-Specific Peptide Presentation

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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk

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Pathogen diversity drives the evolution of generalist MHC-II alleles in human populations

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Genomics of Divergence along a Continuum of Parapatric Population Differentiation

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Excess of Deleterious Mutations around HLA Genes Reveals Evolutionary Cost of Balancing Selection

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Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease

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Ancient DNA study reveals HLA susceptibility locus for leprosy in medieval Europeans

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Admixture as a source for HLA variation in Neolithic European farming communities

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Intronic primers reveal unexpectedly high major histocompatibility complex diversity in Antarctic fur seals

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Immunopeptidomics toolkit library (IPTK): a python-based modular toolbox for analyzing immunopeptidomics data

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Divergent Allele Advantage at Human MHC Genes: Signatures of Past and Ongoing Selection

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Extensive Copy-Number Variation of Young Genes across Stickleback Populations

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Targeted analysis of polymorphic loci from low-coverage shotgun sequence data allows accurate genotyping of HLA genes in historical human populations

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Evaluation of Genetic Diversity and Parasite-Mediated Selection of MHC Class I Genes in Emberiza godlewskii (Passeriformes: Emberizidae)

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Diverse MHC IIB allele repertoire increases parasite resistance and body condition in the Long-tailed giant rat (Leopoldamys sabanus)

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Uterine selection for immunocompetent offspring

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Adaptive value of novel MHC immune gene variants

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