Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
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Author / Creator
Dey, Anwesha , Seshasayee, Dhaya , Noubade, Rajkumar , French, Dorothy M. , Liu, Jinfeng , Chaurushiya, Mira S. , Kirkpatrick, Donald S. , Pham, Victoria C. , Lill, Jennie R. , Bakalarski, Corey E. , Wu, Jiansheng , Phu, Lilian , Katavolos, Paula , LaFave, Lindsay M. , Abdel-Wahab, Omar , Modrusan, Zora , Seshagiri, Somasekar , Dong, Ken , Lin, Zhonghua , Balazs, Mercedesz , Suriben, Rowena , Newton, Kim , Hymowitz, Sarah , Garcia-Manero, Guillermo , Martin, Flavius , Levine, Ross L. and Dixit, Vishva M.
Publisher
Washington, DC: American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
Washington, DC: American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
De-ubiquitinating enzyme BAP1 is mutated in a hereditary cancer syndrome with increased risk of mesothelioma and uveal melanoma. Somatic BAP1 mutations occur in various malignancies. We show that mouse Bap1 gene deletion is lethal during embryogenesis, but systemic or hematopoietic-restricted deletion in adults recapitulates features of human myelo...
Alternative Titles
Full title
Loss of the Tumor Suppressor BAP1 Causes Myeloid Transformation
Authors, Artists and Contributors
Author / Creator
Seshasayee, Dhaya
Noubade, Rajkumar
French, Dorothy M.
Liu, Jinfeng
Chaurushiya, Mira S.
Kirkpatrick, Donald S.
Pham, Victoria C.
Lill, Jennie R.
Bakalarski, Corey E.
Wu, Jiansheng
Phu, Lilian
Katavolos, Paula
LaFave, Lindsay M.
Abdel-Wahab, Omar
Modrusan, Zora
Seshagiri, Somasekar
Dong, Ken
Lin, Zhonghua
Balazs, Mercedesz
Suriben, Rowena
Newton, Kim
Hymowitz, Sarah
Garcia-Manero, Guillermo
Martin, Flavius
Levine, Ross L.
Dixit, Vishva M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5201002
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5201002
Other Identifiers
ISSN
0036-8075
E-ISSN
1095-9203
DOI
10.1126/science.1221711
