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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5228623

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

About this item

Full title

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Publisher

London: Nature Publishing Group UK

Journal title

Nature (London), 2016-08, Vol.536 (7617), p.479-483

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Pancreatic adenocarcinoma cells drive autophagy in tumour microenvironment-associated stellate cells, which release alanine that is used by the cancer cells as a carbon source for a variety of metabolic processes in an otherwise nutrient-poor environment.
A cancer cell support network dissected
Cancer cells generally have metabolic needs that...

Alternative Titles

Full title

Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5228623

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5228623

Other Identifiers

ISSN

0028-0836

E-ISSN

1476-4687

DOI

10.1038/nature19084

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