Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
About this item
Full title
Author / Creator
Yao, Zhan , Yaeger, Rona , Rodrik-Outmezguine, Vanessa S. , Tao, Anthony , Torres, Neilawattie M. , Chang, Matthew T. , Drosten, Matthias , Zhao, Huiyong , Cecchi, Fabiola , Hembrough, Todd , Michels, Judith , Baumert, Hervé , Miles, Linde , Campbell, Naomi M. , de Stanchina, Elisa , Solit, David B. , Barbacid, Mariano , Taylor, Barry S. and Rosen, Neal
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Hypoactive BRAF mutants bind more tightly than wild type to the upstream regulator RAS, thus amplifying to amplify ERK signalling; tumours expressing these mutants require coexistent mechanisms for RAS activation to grow and are sensitive to their inhibition.
Inactive BRAF mutants in cancer
Mutant alleles of the kinase BRAF have been identifi...
Alternative Titles
Full title
Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS
Authors, Artists and Contributors
Author / Creator
Yaeger, Rona
Rodrik-Outmezguine, Vanessa S.
Tao, Anthony
Torres, Neilawattie M.
Chang, Matthew T.
Drosten, Matthias
Zhao, Huiyong
Cecchi, Fabiola
Hembrough, Todd
Michels, Judith
Baumert, Hervé
Miles, Linde
Campbell, Naomi M.
de Stanchina, Elisa
Solit, David B.
Barbacid, Mariano
Taylor, Barry S.
Rosen, Neal
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5648058
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_5648058
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature23291
