Plasticity in binding confers selectivity in ligand-induced protein degradation
Plasticity in binding confers selectivity in ligand-induced protein degradation
About this item
Full title
Author / Creator
Nowak, Radosław P. , DeAngelo, Stephen L. , Buckley, Dennis , He, Zhixiang , Donovan, Katherine A. , An, Jian , Safaee, Nozhat , Jedrychowski, Mark P. , Ponthier, Charles M. , Ishoey, Mette , Zhang, Tinghu , Mancias, Joseph D. , Gray, Nathanael S. , Bradner, James E. , Fischer, Eric S. and Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Heterobifunctional small-molecule degraders that induce protein degradation through ligase-mediated ubiquitination have shown considerable promise as a new pharmacological modality. However, we currently lack a detailed understanding of the molecular basis for target recruitment and selectivity, which is critically required to enable rational desig...
Alternative Titles
Full title
Plasticity in binding confers selectivity in ligand-induced protein degradation
Authors, Artists and Contributors
Author / Creator
DeAngelo, Stephen L.
Buckley, Dennis
He, Zhixiang
Donovan, Katherine A.
An, Jian
Safaee, Nozhat
Jedrychowski, Mark P.
Ponthier, Charles M.
Ishoey, Mette
Zhang, Tinghu
Mancias, Joseph D.
Gray, Nathanael S.
Bradner, James E.
Fischer, Eric S.
Argonne National Lab. (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6202246
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-018-0055-y
