Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
About this item
Full title
Author / Creator
Grevet, Jeremy D , Lan, Xianjiang , Hamagami, Nicole , Edwards, Christopher R , Sankaranarayanan, Laavanya , Ji, Xinjun , Bhardwaj, Saurabh K , Face, Carolyne J , Posocco, David F , Abdulmalik, Osheiza , Keller, Cheryl A , Giardine, Belinda , Sidoli, Simone , Garcia, Ben A , Chou, Stella T , Liebhaber, Stephen A , Hardison, Ross C , Shi, Junwei and Blobel, Gerd A
Publisher
United States: The American Association for the Advancement of Science
Journal title
Language
English
Formats
Publication information
Publisher
United States: The American Association for the Advancement of Science
Subjects
More information
Scope and Contents
Contents
Increasing fetal hemoglobin (HbF) levels in adult red blood cells provides clinical benefit to patients with sickle cell disease and some forms of β-thalassemia. To identify potentially druggable HbF regulators in adult human erythroid cells, we employed a protein kinase domain-focused CRISPR-Cas9-based genetic screen with a newly optimized single-...
Alternative Titles
Full title
Domain-focused CRISPR screen identifies HRI as a fetal hemoglobin regulator in human erythroid cells
Authors, Artists and Contributors
Author / Creator
Lan, Xianjiang
Hamagami, Nicole
Edwards, Christopher R
Sankaranarayanan, Laavanya
Ji, Xinjun
Bhardwaj, Saurabh K
Face, Carolyne J
Posocco, David F
Abdulmalik, Osheiza
Keller, Cheryl A
Giardine, Belinda
Sidoli, Simone
Garcia, Ben A
Chou, Stella T
Liebhaber, Stephen A
Hardison, Ross C
Shi, Junwei
Blobel, Gerd A
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6257981
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6257981
Other Identifiers
ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aao0932
