3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
3-ketodihydrosphingosine reductase (KDSR) is the key enzyme in the
de novo
sphingolipid synthesis. We identified a novel missense
kdsr
I105R
mutation in zebrafish that led to a loss of function, and resulted in progression of hepatomegaly to steatosis, then hepatic injury phenotype. Lipidomics analysis of the
kdsr
I105R
muta...
Alternative Titles
Full title
3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6361991
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6361991
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-018-37946-0
