Discovery of NV-5138, the first selective Brain mTORC1 activator
Discovery of NV-5138, the first selective Brain mTORC1 activator
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
The mechanistic target of rapamycin complex 1 (mTORC1) has been linked to several important chronic medical conditions many of which are associated with advancing age. A variety of inputs including the amino acid leucine are required for full mTORC1 activation. The cytoplasmic proteins Sestrin1 and Sestrin2 specifically bind to the multiprotein com...
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Full title
Discovery of NV-5138, the first selective Brain mTORC1 activator
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6412019
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6412019
Other Identifiers
ISSN
2045-2322
E-ISSN
2045-2322
DOI
10.1038/s41598-019-40693-5
