Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
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Publisher
London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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The authors show that p53 helps cancer cells survive serine depletion by coordinating metabolic remodelling; a diet lacking serine slowed tumour growth in mice, with p53-null tumours showing greatest sensitivity to serine starvation.
Serine deprivation as anticancer mechanism
The tumour suppressor p53 functions in a number of stress-response...
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Full title
Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6485472
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6485472
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ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature11743
