NMNAT2‐mediated NAD+ generation is essential for quality control of aged oocytes
NMNAT2‐mediated NAD+ generation is essential for quality control of aged oocytes
About this item
Full title
Author / Creator
Wu, Xinghan , Hu, Feifei , Zeng, Juan , Han, Longsen , Qiu, Danhong , Wang, Haichao , Ge, Juan , Ying, Xiaoyan and Wang, Qiang
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
Formats
Publication information
Publisher
England: John Wiley & Sons, Inc
Subjects
More information
Scope and Contents
Contents
Advanced maternal age has been reported to impair oocyte quality; however, the underlying mechanisms remain to be explored. In the present study, we identified the lowered NAD+ content and decreased expression of NMNAT2 protein in oocytes from old mice. Specific depletion of NMNAT2 in mouse oocytes disturbs the meiotic apparatus assembly and metabo...
Alternative Titles
Full title
NMNAT2‐mediated NAD+ generation is essential for quality control of aged oocytes
Authors, Artists and Contributors
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6516161
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6516161
Other Identifiers
ISSN
1474-9718
E-ISSN
1474-9726
DOI
10.1111/acel.12955
