ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem...
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
About this item
Full title
Author / Creator
Mistry, Jayna J. , Marlein, Christopher R. , Moore, Jamie A. , Hellmich, Charlotte , Wojtowicz, Edyta E. , Smith, James G. W. , Macaulay, Iain , Sun, Yu , Morfakis, Adam , Patterson, Angela , Horton, Rebecca H. , Divekar, Devina , Morris, Christopher J. , Haestier, Anna , Di Palma, Federica , Beraza, Naiara , Bowles, Kristian M. and Rushworth, Stuart A.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Hematopoietic stem cells (HSCs) undergo rapid expansion in response to stress stimuli. Here we investigate the bioenergetic processes which facilitate the HSC expansion in response to infection. We find that infection by Gram-negative bacteria drives an increase in mitochondrial mass in mammalian HSCs, which results in a metabolic transition from g...
Alternative Titles
Full title
ROS-mediated PI3K activation drives mitochondrial transfer from stromal cells to hematopoietic stem cells in response to infection
Authors, Artists and Contributors
Author / Creator
Marlein, Christopher R.
Moore, Jamie A.
Hellmich, Charlotte
Wojtowicz, Edyta E.
Smith, James G. W.
Macaulay, Iain
Sun, Yu
Morfakis, Adam
Patterson, Angela
Horton, Rebecca H.
Divekar, Devina
Morris, Christopher J.
Haestier, Anna
Di Palma, Federica
Beraza, Naiara
Bowles, Kristian M.
Rushworth, Stuart A.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6900710
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6900710
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.1913278116
