Brd4 inhibition ameliorates Pyocyanin-mediated macrophage dysfunction via transcriptional repression...
Brd4 inhibition ameliorates Pyocyanin-mediated macrophage dysfunction via transcriptional repression of reactive oxygen and nitrogen free radical pathways
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Author / Creator
Zhu, Feimei , Xiong, Feng , He, Jinchen , Liu, Keyun , You, Yuanyuan , Xu, Qian , Miao, Junming , Du, Yu , Zhang, Lijuan , Ren, Hongyu , Wang, Xiaoying , Chen, Junli , Li, Jingyu , Chen, Shanze , Liu, Xiaokang , Huang, Ning and Wang, Yi
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Contents
Macrophages play critical roles in the first-line immune defense against airway infections caused by
Pseudomonas aeruginosa
(PA). The redox-active phenazine-pyocyanin (PCN), as one of the most essential virulence factors, facilities PA-related infection via a wide spectrum of cellular oxidative damages. However, little is known for PCN cytoto...
Alternative Titles
Full title
Brd4 inhibition ameliorates Pyocyanin-mediated macrophage dysfunction via transcriptional repression of reactive oxygen and nitrogen free radical pathways
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7295752
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7295752
Other Identifiers
ISSN
2041-4889
E-ISSN
2041-4889
DOI
10.1038/s41419-020-2672-0
