Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three an...
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
About this item
Full title
Author / Creator
Li, Wei , Chen, Chuan , Drelich, Aleksandra , Martinez, David R. , Gralinski, Lisa E. , Sun, Zehua , Schäfer, Alexandra , Kulkarni, Swarali S. , Liu, Xianglei , Leist, Sarah R. , Zhelev, Doncho V. , Zhang, Liyong , Kim, Ye-Jin , Peterson, Eric C. , Conard, Alex , Mellors, John W. , Tseng, Chien-Te K. , Falzarano, Darryl , Baric, Ralph S. and Dimitrov, Dimiter S.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Effective therapies are urgently needed for the SARS-CoV-2/COVID-19 pandemic. We identified panels of fully human monoclonal antibodies (mAbs) from large phage-displayed Fab, scFv, and VH libraries by panning against the receptor binding domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. A high-affinity Fab was selected from one of the librarie...
Alternative Titles
Full title
Rapid identification of a human antibody with high prophylactic and therapeutic efficacy in three animal models of SARS-CoV-2 infection
Authors, Artists and Contributors
Author / Creator
Chen, Chuan
Drelich, Aleksandra
Martinez, David R.
Gralinski, Lisa E.
Sun, Zehua
Schäfer, Alexandra
Kulkarni, Swarali S.
Liu, Xianglei
Leist, Sarah R.
Zhelev, Doncho V.
Zhang, Liyong
Kim, Ye-Jin
Peterson, Eric C.
Conard, Alex
Mellors, John W.
Tseng, Chien-Te K.
Falzarano, Darryl
Baric, Ralph S.
Dimitrov, Dimiter S.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7703590
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7703590
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2010197117
