Small-molecule-induced polymerization triggers degradation of BCL6
Small-molecule-induced polymerization triggers degradation of BCL6
About this item
Full title
Author / Creator
Słabicki, Mikołaj , Yoon, Hojong , Koeppel, Jonas , Nitsch, Lena , Roy Burman, Shourya S. , Di Genua, Cristina , Donovan, Katherine A. , Sperling, Adam S. , Hunkeler, Moritz , Tsai, Jonathan M. , Sharma, Rohan , Guirguis, Andrew , Zou, Charles , Chudasama, Priya , Gasser, Jessica A. , Miller, Peter G. , Scholl, Claudia , Fröhling, Stefan , Nowak, Radosław P. , Fischer, Eric S. and Ebert, Benjamin L.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Effective and sustained inhibition of non-enzymatic oncogenic driver proteins is a major pharmacological challenge. The clinical success of thalidomide analogues demonstrates the therapeutic efficacy of drug-induced degradation of transcription factors and other cancer targets
1
–
3
, but a substantial subset of proteins are resistant t...
Alternative Titles
Full title
Small-molecule-induced polymerization triggers degradation of BCL6
Authors, Artists and Contributors
Author / Creator
Yoon, Hojong
Koeppel, Jonas
Nitsch, Lena
Roy Burman, Shourya S.
Di Genua, Cristina
Donovan, Katherine A.
Sperling, Adam S.
Hunkeler, Moritz
Tsai, Jonathan M.
Sharma, Rohan
Guirguis, Andrew
Zou, Charles
Chudasama, Priya
Gasser, Jessica A.
Miller, Peter G.
Scholl, Claudia
Fröhling, Stefan
Nowak, Radosław P.
Fischer, Eric S.
Ebert, Benjamin L.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7816212
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7816212
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-020-2925-1
