Augmenting and directing long-range CRISPR-mediated activation in human cells
Augmenting and directing long-range CRISPR-mediated activation in human cells
About this item
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Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Epigenetic editing is an emerging technology that uses artificial transcription factors (aTFs) to regulate expression of a target gene. Although human genes can be robustly upregulated by targeting aTFs to promoters, the activation induced by directing aTFs to distal transcriptional enhancers is substantially less robust and consistent. Here we sho...
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Full title
Augmenting and directing long-range CRISPR-mediated activation in human cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8446310
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8446310
Other Identifiers
ISSN
1548-7091
E-ISSN
1548-7105
DOI
10.1038/s41592-021-01224-1
