A glycan gate controls opening of the SARS-CoV-2 spike protein
A glycan gate controls opening of the SARS-CoV-2 spike protein
About this item
Full title
Author / Creator
Sztain, Terra , Ahn, Surl-Hee , Bogetti, Anthony T. , Casalino, Lorenzo , Goldsmith, Jory A. , Seitz, Evan , McCool, Ryan S. , Kearns, Fiona L. , Acosta-Reyes, Francisco , Maji, Suvrajit , Mashayekhi, Ghoncheh , McCammon, J. Andrew , Ourmazd, Abbas , Frank, Joachim , McLellan, Jason S. , Chong, Lillian T. , Amaro, Rommie E. and Univ. of Wisconsin, Madison, WI (United States)
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
SARS-CoV-2 infection is controlled by the opening of the spike protein receptor binding domain (RBD), which transitions from a glycan-shielded ‘down’ to an exposed ‘up’ state to bind the human angiotensin-converting enzyme 2 receptor and infect cells. While snapshots of the ‘up’ and ‘down’ states have been obtained by cryo-electron microscopy and c...
Alternative Titles
Full title
A glycan gate controls opening of the SARS-CoV-2 spike protein
Authors, Artists and Contributors
Author / Creator
Ahn, Surl-Hee
Bogetti, Anthony T.
Casalino, Lorenzo
Goldsmith, Jory A.
Seitz, Evan
McCool, Ryan S.
Kearns, Fiona L.
Acosta-Reyes, Francisco
Maji, Suvrajit
Mashayekhi, Ghoncheh
McCammon, J. Andrew
Ourmazd, Abbas
Frank, Joachim
McLellan, Jason S.
Chong, Lillian T.
Amaro, Rommie E.
Univ. of Wisconsin, Madison, WI (United States)
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8488004
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8488004
Other Identifiers
ISSN
1755-4330
E-ISSN
1755-4349
DOI
10.1038/s41557-021-00758-3
