Discovery and resistance mechanism of a selective CDK12 degrader
Discovery and resistance mechanism of a selective CDK12 degrader
About this item
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Author / Creator
Jiang, Baishan , Gao, Yang , Che, Jianwei , Lu, Wenchao , Kaltheuner, Ines H. , Dries, Ruben , Kalocsay, Marian , Berberich, Matthew J. , Jiang, Jie , You, Inchul , Kwiatkowski, Nicholas , Riching, Kristin M. , Daniels, Danette L. , Sorger, Peter K. , Geyer, Matthias , Zhang, Tinghu and Gray, Nathanael S.
Publisher
New York: Nature Publishing Group US
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Language
English
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Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Cyclin-dependent kinase 12 (CDK12) is an emerging therapeutic target due to its role in regulating transcription of DNA-damage response (DDR) genes. However, development of selective small molecules targeting CDK12 has been challenging due to the high degree of homology between kinase domains of CDK12 and other transcriptional CDKs, most notably CD...
Alternative Titles
Full title
Discovery and resistance mechanism of a selective CDK12 degrader
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8590456
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8590456
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-021-00765-y
