Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
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Author / Creator
Jerby-Arnon, Livnat , Neftel, Cyril , Shore, Marni E. , Weisman, Hannah R. , Mathewson, Nathan D. , McBride, Matthew J. , Haas, Brian , Izar, Benjamin , Volorio, Angela , Boulay, Gaylor , Cironi, Luisa , Richman, Alyssa R. , Broye, Liliane C. , Gurski, Joseph M. , Luo, Christina C. , Mylvaganam, Ravindra , Nguyen, Lan , Mei, Shaolin , Melms, Johannes C. , Georgescu, Christophe , Cohen, Ofir , Buendia-Buendia, Jorge E. , Segerstolpe, Asa , Sud, Malika , Cuoco, Michael S. , Labes, Danny , Gritsch, Simon , Zollinger, Daniel R. , Ortogero, Nicole , Beechem, Joseph M. , Petur Nielsen, G. , Chebib, Ivan , Nguyen-Ngoc, Tu , Montemurro, Michael , Cote, Gregory M. , Choy, Edwin , Letovanec, Igor , Cherix, Stéphane , Wagle, Nikhil , Sorger, Peter K. , Haynes, Alex B. , Mullen, John T. , Stamenkovic, Ivan , Rivera, Miguel N. , Kadoch, Cigall , Wucherpfennig, Kai W. , Rozenblatt-Rosen, Orit , Suvà, Mario L. , Riggi, Nicolò and Regev, Aviv
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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Scope and Contents
Contents
Synovial sarcoma (SyS) is an aggressive neoplasm driven by the SS18–SSX fusion, and is characterized by low T cell infiltration. Here, we studied the cancer–immune interplay in SyS using an integrative approach that combines single-cell RNA sequencing (scRNA-seq), spatial profiling and genetic and pharmacological perturbations. scRNA-seq of 16,872...
Alternative Titles
Full title
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma
Authors, Artists and Contributors
Author / Creator
Neftel, Cyril
Shore, Marni E.
Weisman, Hannah R.
Mathewson, Nathan D.
McBride, Matthew J.
Haas, Brian
Izar, Benjamin
Volorio, Angela
Boulay, Gaylor
Cironi, Luisa
Richman, Alyssa R.
Broye, Liliane C.
Gurski, Joseph M.
Luo, Christina C.
Mylvaganam, Ravindra
Nguyen, Lan
Mei, Shaolin
Melms, Johannes C.
Georgescu, Christophe
Cohen, Ofir
Buendia-Buendia, Jorge E.
Segerstolpe, Asa
Sud, Malika
Cuoco, Michael S.
Labes, Danny
Gritsch, Simon
Zollinger, Daniel R.
Ortogero, Nicole
Beechem, Joseph M.
Petur Nielsen, G.
Chebib, Ivan
Nguyen-Ngoc, Tu
Montemurro, Michael
Cote, Gregory M.
Choy, Edwin
Letovanec, Igor
Cherix, Stéphane
Wagle, Nikhil
Sorger, Peter K.
Haynes, Alex B.
Mullen, John T.
Stamenkovic, Ivan
Rivera, Miguel N.
Kadoch, Cigall
Wucherpfennig, Kai W.
Rozenblatt-Rosen, Orit
Suvà, Mario L.
Riggi, Nicolò
Regev, Aviv
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8817899
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8817899
Other Identifiers
ISSN
1078-8956,1546-170X
E-ISSN
1546-170X
DOI
10.1038/s41591-020-01212-6
