A conformational switch controlling the toxicity of the prion protein
A conformational switch controlling the toxicity of the prion protein
About this item
Full title
Author / Creator
Frontzek, Karl , Bardelli, Marco , Senatore, Assunta , Henzi, Anna , Reimann, Regina R. , Bedir, Seden , Marino, Marika , Hussain, Rohanah , Jurt, Simon , Meisl, Georg , Pedotti, Mattia , Mazzola, Federica , Siligardi, Giuliano , Zerbe, Oliver , Losa, Marco , Knowles, Tuomas , Lakkaraju, Asvin , Zhu, Caihong , Schwarz, Petra , Hornemann, Simone , Holt, Matthew G. , Simonelli, Luca , Varani, Luca and Aguzzi, Adriano
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Prion infections cause conformational changes of the cellular prion protein (PrP
C
) and lead to progressive neurological impairment. Here we show that toxic, prion-mimetic ligands induce an intramolecular R208-H140 hydrogen bond (‘H-latch’), altering the flexibility of the α2–α3 and β2–α2 loops of PrP
C
. Expression of a PrP
2Cys
Alternative Titles
Full title
A conformational switch controlling the toxicity of the prion protein
Authors, Artists and Contributors
Author / Creator
Bardelli, Marco
Senatore, Assunta
Henzi, Anna
Reimann, Regina R.
Bedir, Seden
Marino, Marika
Hussain, Rohanah
Jurt, Simon
Meisl, Georg
Pedotti, Mattia
Mazzola, Federica
Siligardi, Giuliano
Zerbe, Oliver
Losa, Marco
Knowles, Tuomas
Lakkaraju, Asvin
Zhu, Caihong
Schwarz, Petra
Hornemann, Simone
Holt, Matthew G.
Simonelli, Luca
Varani, Luca
Aguzzi, Adriano
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9371974
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9371974
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-022-00814-7
