GPCRmd uncovers the dynamics of the 3D-GPCRome
GPCRmd uncovers the dynamics of the 3D-GPCRome
About this item
Full title
Author / Creator
Rodríguez-Espigares, Ismael , Torrens-Fontanals, Mariona , Tiemann, Johanna K. S. , Aranda-García, David , Ramírez-Anguita, Juan Manuel , Stepniewski, Tomasz Maciej , Worp, Nathalie , Varela-Rial, Alejandro , Morales-Pastor, Adrián , Medel-Lacruz, Brian , Pándy-Szekeres, Gáspár , Mayol, Eduardo , Giorgino, Toni , Carlsson, Jens , Deupi, Xavier , Filipek, Slawomir , Filizola, Marta , Gómez-Tamayo, José Carlos , Gonzalez, Angel , Gutiérrez-de-Terán, Hugo , Jiménez-Rosés, Mireia , Jespers, Willem , Kapla, Jon , Khelashvili, George , Kolb, Peter , Latek, Dorota , Marti-Solano, Maria , Matricon, Pierre , Matsoukas, Minos-Timotheos , Miszta, Przemyslaw , Olivella, Mireia , Perez-Benito, Laura , Provasi, Davide , Ríos, Santiago , R. Torrecillas, Iván , Sallander, Jessica , Sztyler, Agnieszka , Vasile, Silvana , Weinstein, Harel , Zachariae, Ulrich , Hildebrand, Peter W. , De Fabritiis, Gianni , Sanz, Ferran , Gloriam, David E. , Cordomi, Arnau , Guixà-González, Ramon and Selent, Jana
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
G-protein-coupled receptors (GPCRs) are involved in numerous physiological processes and are the most frequent targets of approved drugs. The explosion in the number of new three-dimensional (3D) molecular structures of GPCRs (3D-GPCRome) over the last decade has greatly advanced the mechanistic understanding and drug design opportunities for this protein family. Molecular dynamics (MD) simulations have become a widely established technique for exploring the conformational landscape of proteins at an atomic level. However, the analysis and visualization of MD simulations require efficient storage resources and specialized software. Here we present GPCRmd (
http://gpcrmd.org/
), an online platform that incorporates web-based visualization capabilities as well as a comprehensive and user-friendly analysis toolbox that allows scientists from different disciplines to visualize, analyze and share GPCR MD data. GPCRmd originates from a community-driven effort to create an open, interactive and standardized database o...
Alternative Titles
Full title
GPCRmd uncovers the dynamics of the 3D-GPCRome
Authors, Artists and Contributors
Author / Creator
Torrens-Fontanals, Mariona
Tiemann, Johanna K. S.
Aranda-García, David
Ramírez-Anguita, Juan Manuel
Stepniewski, Tomasz Maciej
Worp, Nathalie
Varela-Rial, Alejandro
Morales-Pastor, Adrián
Medel-Lacruz, Brian
Pándy-Szekeres, Gáspár
Mayol, Eduardo
Giorgino, Toni
Carlsson, Jens
Deupi, Xavier
Filipek, Slawomir
Filizola, Marta
Gómez-Tamayo, José Carlos
Gonzalez, Angel
Gutiérrez-de-Terán, Hugo
Jiménez-Rosés, Mireia
Jespers, Willem
Kapla, Jon
Khelashvili, George
Kolb, Peter
Latek, Dorota
Marti-Solano, Maria
Matricon, Pierre
Matsoukas, Minos-Timotheos
Miszta, Przemyslaw
Olivella, Mireia
Perez-Benito, Laura
Provasi, Davide
Ríos, Santiago
R. Torrecillas, Iván
Sallander, Jessica
Sztyler, Agnieszka
Vasile, Silvana
Weinstein, Harel
Zachariae, Ulrich
Hildebrand, Peter W.
De Fabritiis, Gianni
Sanz, Ferran
Gloriam, David E.
Cordomi, Arnau
Guixà-González, Ramon
Selent, Jana
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_DiVA_org_uu_423639
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_DiVA_org_uu_423639
Other Identifiers
ISSN
1548-7091,1548-7105
E-ISSN
1548-7105
DOI
10.1038/s41592-020-0884-y
