FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
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Author / Creator
Brevini, Teresa , Maes, Mailis , Webb, Gwilym J. , John, Binu V. , Fuchs, Claudia D. , Buescher, Gustav , Wang, Lu , Griffiths, Chelsea , Brown, Marnie L. , Scott, William E. , Pereyra-Gerber, Pehuén , Gelson, William T. H. , Brown, Stephanie , Dillon, Scott , Muraro, Daniele , Sharp, Jo , Neary, Megan , Box, Helen , Tatham, Lee , Stewart, James , Curley, Paul , Pertinez, Henry , Forrest, Sally , Mlcochova, Petra , Varankar, Sagar S. , Darvish-Damavandi, Mahnaz , Mulcahy, Victoria L. , Kuc, Rhoda E. , Williams, Thomas L. , Heslop, James A. , Rossetti, Davide , Tysoe, Olivia C. , Galanakis, Vasileios , Vila-Gonzalez, Marta , Crozier, Thomas W. M. , Bargehr, Johannes , Sinha, Sanjay , Upponi, Sara S. , Fear, Corrina , Swift, Lisa , Saeb-Parsy, Kourosh , Davies, Susan E. , Wester, Axel , Hagström, Hannes , Melum, Espen , Clements, Darran , Humphreys, Peter , Herriott, Jo , Kijak, Edyta , Cox, Helen , Bramwell, Chloe , Valentijn, Anthony , Illingworth, Christopher J. R. , Dahman, Bassam , Bastaich, Dustin R. , Ferreira, Raphaella D. , Marjot, Thomas , Barnes, Eleanor , Moon, Andrew M. , Barritt, Alfred S. , Gupta, Ravindra K. , Baker, Stephen , Davenport, Anthony P. , Corbett, Gareth , Gorgoulis, Vassilis G. , Buczacki, Simon J. A. , Lee, Joo-Hyeon , Matheson, Nicholas J. , Trauner, Michael , Fisher, Andrew J. , Gibbs, Paul , Butler, Andrew J. , Watson, Christopher J. E. , Mells, George F. , Dougan, Gordon , Owen, Andrew , Lohse, Ansgar W. , Vallier, Ludovic , Sampaziotis, Fotios and UK-PBC Consortium
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Preventing SARS-CoV-2 infection by modulating viral host receptors, such as angiotensin-converting enzyme 2 (ACE2)
1
, could represent a new chemoprophylactic approach for COVID-19 that complements vaccination
2
,
3
. However, the mechanisms that control the expression of ACE2 remain unclear. Here we show that the farnesoid X rece...
Alternative Titles
Full title
FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2
Authors, Artists and Contributors
Author / Creator
Maes, Mailis
Webb, Gwilym J.
John, Binu V.
Fuchs, Claudia D.
Buescher, Gustav
Wang, Lu
Griffiths, Chelsea
Brown, Marnie L.
Scott, William E.
Pereyra-Gerber, Pehuén
Gelson, William T. H.
Brown, Stephanie
Dillon, Scott
Muraro, Daniele
Sharp, Jo
Neary, Megan
Box, Helen
Tatham, Lee
Stewart, James
Curley, Paul
Pertinez, Henry
Forrest, Sally
Mlcochova, Petra
Varankar, Sagar S.
Darvish-Damavandi, Mahnaz
Mulcahy, Victoria L.
Kuc, Rhoda E.
Williams, Thomas L.
Heslop, James A.
Rossetti, Davide
Tysoe, Olivia C.
Galanakis, Vasileios
Vila-Gonzalez, Marta
Crozier, Thomas W. M.
Bargehr, Johannes
Sinha, Sanjay
Upponi, Sara S.
Fear, Corrina
Swift, Lisa
Saeb-Parsy, Kourosh
Davies, Susan E.
Wester, Axel
Hagström, Hannes
Melum, Espen
Clements, Darran
Humphreys, Peter
Herriott, Jo
Kijak, Edyta
Cox, Helen
Bramwell, Chloe
Valentijn, Anthony
Illingworth, Christopher J. R.
Dahman, Bassam
Bastaich, Dustin R.
Ferreira, Raphaella D.
Marjot, Thomas
Barnes, Eleanor
Moon, Andrew M.
Barritt, Alfred S.
Gupta, Ravindra K.
Baker, Stephen
Davenport, Anthony P.
Corbett, Gareth
Gorgoulis, Vassilis G.
Buczacki, Simon J. A.
Lee, Joo-Hyeon
Matheson, Nicholas J.
Trauner, Michael
Fisher, Andrew J.
Gibbs, Paul
Butler, Andrew J.
Watson, Christopher J. E.
Mells, George F.
Dougan, Gordon
Owen, Andrew
Lohse, Ansgar W.
Vallier, Ludovic
Sampaziotis, Fotios
UK-PBC Consortium
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_449192
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_449192
Other Identifiers
ISSN
0028-0836,1476-4687
E-ISSN
1476-4687
DOI
10.1038/s41586-022-05594-0
