Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
About this item
Full title
Author / Creator
Fenaux, Pierre , Platzbecker, Uwe , Mufti, Ghulam J , Garcia-Manero, Guillermo , Buckstein, Rena , Santini, Valeria , Díez-Campelo, María , Finelli, Carlo , Cazzola, Mario , Ilhan, Osman , Sekeres, Mikkael A , Falantes, José F , Arrizabalaga, Beatriz , Salvi, Flavia , Giai, Valentina , Vyas, Paresh , Bowen, David , Selleslag, Dominik , DeZern, Amy E , Jurcic, Joseph G , Germing, Ulrich , Götze, Katharina S , Quesnel, Bruno , Beyne-Rauzy, Odile , Cluzeau, Thomas , Voso, Maria-Teresa , Mazure, Dominiek , Vellenga, Edo , Greenberg, Peter L , Hellström-Lindberg, Eva , Zeidan, Amer M , Adès, Lionel , Verma, Amit , Savona, Michael R , Laadem, Abderrahmane , Benzohra, Aziz , Zhang, Jennie , Rampersad, Anita , Dunshee, Diana R , Linde, Peter G , Sherman, Matthew L , Komrokji, Rami S and List, Alan F
Publisher
United States: Massachusetts Medical Society
Journal title
Language
English
Formats
Publication information
Publisher
United States: Massachusetts Medical Society
Subjects
More information
Scope and Contents
Contents
Luspatercept is a fusion protein aimed at binding TGF-β family members and reducing SMAD2 and SMAD3 signaling in patients with myelodysplasia with ring sideroblasts. In a randomized trial involving transfusion-dependent patients with lower-risk disease, transfusion independence for 8 weeks or longer occurred in 38% of patients in the luspatercept g...
Alternative Titles
Full title
Luspatercept in Patients with Lower-Risk Myelodysplastic Syndromes
Authors, Artists and Contributors
Author / Creator
Platzbecker, Uwe
Mufti, Ghulam J
Garcia-Manero, Guillermo
Buckstein, Rena
Santini, Valeria
Díez-Campelo, María
Finelli, Carlo
Cazzola, Mario
Ilhan, Osman
Sekeres, Mikkael A
Falantes, José F
Arrizabalaga, Beatriz
Salvi, Flavia
Giai, Valentina
Vyas, Paresh
Bowen, David
Selleslag, Dominik
DeZern, Amy E
Jurcic, Joseph G
Germing, Ulrich
Götze, Katharina S
Quesnel, Bruno
Beyne-Rauzy, Odile
Cluzeau, Thomas
Voso, Maria-Teresa
Mazure, Dominiek
Vellenga, Edo
Greenberg, Peter L
Hellström-Lindberg, Eva
Zeidan, Amer M
Adès, Lionel
Verma, Amit
Savona, Michael R
Laadem, Abderrahmane
Benzohra, Aziz
Zhang, Jennie
Rampersad, Anita
Dunshee, Diana R
Linde, Peter G
Sherman, Matthew L
Komrokji, Rami S
List, Alan F
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_474431
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_474431
Other Identifiers
ISSN
0028-4793
E-ISSN
1533-4406
DOI
10.1056/NEJMoa1908892
