Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruni...
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
About this item
Full title
Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse elimination in patient-derived neural cultures and isolated synaptosomes. This excessive synaptic p...
Alternative Titles
Full title
Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_482243
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_482243
Other Identifiers
ISSN
1097-6256
E-ISSN
1546-1726
DOI
10.1038/s41593-018-0334-7
