Engineered CRISPR-Cas9 nucleases with altered PAM specificities
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
CRISPR-Cas9 nucleases are widely used for genome editing, but the range of sequences that Cas9 can recognize is constrained by the need for a specific protospacer adjacent motif (PAM); here the commonly used Streptococcus pyogenes Cas9 (SpCas9) is modified to recognize alternative PAM sequences, enabling robust editing of endogenous gene sites in z...
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Full title
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
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Record Identifier
TN_cdi_swepub_primary_oai_swepub_ki_se_512612
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_swepub_primary_oai_swepub_ki_se_512612
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/nature14592
