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Select record 21
ArticlesPeer ReviewedFull Text
T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells
Author / Creator:Heuser, C ; Hombach, A ; Lösch, C ; Manista, K ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:Gene therapy, 2003-08, Vol.10 (17), p.1408-1419
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A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3ζ-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells
Author / Creator:Hombach, A ; Schlimper, C ; Sievers, E ; Frank, S ; Schild, H H ; Sauerbruch, T ; Schmidt-Wolf, I G H ; Abken, H
Publisher:BMJ Publishing Group Ltd and British Society of Gastroenterology
Journal title:Gut, 2006-08, Vol.55 (8), p.1156-1164
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An anti-MUC1-antibody–interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells
Author / Creator:Heuser, C ; Ganser, M ; Hombach, A ; Brand, H ; Denton, G ; Hanisch, F-G ; Abken, H
Publisher:London: Nature Publishing Group UK
Journal title:British journal of cancer, 2003-09, Vol.89 (6), p.1130-1139
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A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA
Author / Creator:Hombach, A ; Koch, D ; Sircar, R ; Heuser, C ; Diehl, V ; Kruis, W ; Pohl, C ; Abken, H
Publisher:Basingstoke: Nature Publishing Group
Journal title:Gene therapy, 1999-02, Vol.6 (2), p.300-304
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Immune Response Manipulation: Recombinant Immunoreceptors Endow T-Cells with Predefined Specificity
Author / Creator:Abken, Hinrich ; Hombach, Andreas ; Heuser, Claudia
Publisher:Hilversum: Bentham Science Publishers Ltd
Journal title:Current pharmaceutical design, 2003-01, Vol.9 (24), p.1992-2001
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Dermal Fibroblasts Sustain Proliferation of Activated T Cells via Membrane-Bound Interleukin-15 upon Long-Term Stimulation with Tumor Necrosis Factor-α
Author / Creator:Kapsokefalou, Anna ; Heuser, Claudia ; Abken, Hinrich ; Rappl, Gunter ; Röβler, Martin ; Ugurel, Selma ; Tilgen, Wolfgang ; Reinhold, Uwe
Publisher:Danvers, MA: Elsevier Inc
Journal title:Journal of investigative dermatology, 2001-01, Vol.116 (1), p.102-109
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T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30+ cutaneous lymphoma cells
Author / Creator:Hombach, A ; Muche, J M ; Gerken, M ; Gellrich, S ; Heuser, C ; Pohl, C ; Sterry, W ; Abken, H
Publisher:Basingstoke: Nature Publishing Group
Journal title:Gene therapy, 2001-06, Vol.8 (11), p.891-895
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T cell activation by recombinant FcεRI γ-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition
Author / Creator:Hombach, A ; Heuser, C ; Gerken, M ; Fischer, B ; Lewalter, K ; Diehl, V ; Pohl, C ; Abken, H
Publisher:Houndmills: Nature Publishing Group
Journal title:Gene therapy, 2000-06, Vol.7 (12), p.1067-1075
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Engineered T cells redirected by 2nd and 3rd generation immunoreceptors - The weal and woe of costimulation
Author / Creator:Abken, H
Journal title:Human gene therapy, 2009-11, Vol.20 (11), p.1360-1360
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S80. Prolongation of T cell response by OX40 co-signalling CARS
Author / Creator:Abken, H
Publisher:London: BMJ Publishing Group LTD
Journal title:Journal for immunotherapy of cancer, 2014-03, Vol.2 (S2), p.I18-I18, Article I18
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Select record 31
ArticlesPeer ReviewedFull Text
A dual chain chimeric antigen receptor
Author / Creator:Nagy, V ; Abken, H ; Hombach, A.A ; Faitschuk, E
Publisher:Nature Publishing Group
Journal title:Gene therapy, 2016-10, Vol.23 (10), p.718
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Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas
Author / Creator:Kruschinski, Anna ; Moosmann, Andreas ; Poschke, Isabel ; Norell, Håkan ; Chmielewski, Markus ; Seliger, Barbara ; Kiessling, Rolf ; Blankenstein, Thomas ; Abken, Hinrich ; Charo, Jehad
Publisher:United States: National Academy of Sciences
Journal title:Proceedings of the National Academy of Sciences - PNAS, 2008-11, Vol.105 (45), p.17481-17486
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ArticlesPeer ReviewedFull Text
T cells redirected by a CD3[zeta] chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term
Author / Creator:Chmielewski, M ; Rappl, G ; Hombach, A A ; Abken, H
Publisher:Houndmills: Nature Publishing Group
Journal title:Gene therapy, 2013-02, Vol.20 (2), p.177
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ArticlesPeer ReviewedFull Text
T cells redirected by a CD3θ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term
Author / Creator:Chmielewski, M ; Rappl, G ; Hombach, A.A ; Abken, H
Publisher:Nature Publishing Group
Journal title:Gene therapy, 2013-02, Vol.20 (2), p.177
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Select record 35
ArticlesPeer ReviewedFull Text
Adoptive immunotherapy with genetically engineered T cells: modification of the IgG 1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and un...
Author / Creator:HOMBACH, A ; HOMBACH, A. A ; ABKEN, H
Publisher:London: Nature Publishing Group
Journal title:Gene therapy, 2010, Vol.17 (10), p.1206-1213
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Select record 36
ArticlesPeer ReviewedFull Text
Short DNA Sequences from the Cytoplasm of Mouse Tumor Cells Induce Immortalization of Human Lymphocytes in vitro
Author / Creator:Abken, Hinrich ; Hegger, Ralf ; Butzler, Christoph ; Willecke, Klaus
Publisher:Washington, DC: National Academy of Sciences of the United States of America
Journal title:Proceedings of the National Academy of Sciences - PNAS, 1993-07, Vol.90 (14), p.6518-6522
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Select record 37
ArticlesPeer ReviewedFull Text
Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy
Author / Creator:Hombach, Andreas ; Abken, Hinrich
Publisher:Germany: Berlin/Heidelberg : Springer-Verlag
Journal title:Cancer Immunology, Immunotherapy, 2007-05, Vol.56 (5), p.731-737
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Select record 38
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Genetic engineering of human CD4+ CD25+ regulatory T cells with pre-defined target specificity
Author / Creator:Hombach, A ; Kofler, D ; Rappl, G ; Abken, H
Journal title:Human gene therapy, 2009-11, Vol.20 (11), p.1398-1398
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Select record 39
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Redirecting human CD4 super(+)CD25 super(+) regulatory T cells from the peripheral blood with pre-defined target specificity
Author / Creator:Hombach, A A ; Kofler, D ; Rappl, G ; Abken, H
Journal title:Gene therapy, 2009-09, Vol.16 (9), p.1088-1096
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Select record 40
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Redirecting human [CD4.sup.+][CD25.sup.+] regulatory T cells from the peripheral blood with pre-defined target specificity
Author / Creator:Hombach, A.A ; Kofler, D ; Rappl, G ; Abken, H
Publisher:Nature Publishing Group
Journal title:Gene therapy, 2009-09, Vol.16 (9), p.1088
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Showing 21 to 40 of 56 results

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T-cell activation by recombinant immunoreceptors: Impact of the intracellular signalling domain on the stability of receptor expression and antigen-specific activation of grafted T cells

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A recombinant anti-carcinoembryonic antigen immunoreceptor with combined CD3ζ-CD28 signalling targets T cells from colorectal cancer patients against their tumour cells

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An anti-MUC1-antibody–interleukin-2 fusion protein that activates resting NK cells to lysis of MUC1-positive tumour cells

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A chimeric receptor that selectively targets membrane-bound carcinoembryonic antigen (mCEA) in the presence of soluble CEA

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Immune Response Manipulation: Recombinant Immunoreceptors Endow T-Cells with Predefined Specificity

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Dermal Fibroblasts Sustain Proliferation of Activated T Cells via Membrane-Bound Interleukin-15 upon Long-Term Stimulation with Tumor Necrosis Factor-α

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T cells engrafted with a recombinant anti-CD30 receptor target autologous CD30+ cutaneous lymphoma cells

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T cell activation by recombinant FcεRI γ-chain immune receptors: an extracellular spacer domain impairs antigen-dependent T cell activation but not antigen recognition

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Engineered T cells redirected by 2nd and 3rd generation immunoreceptors - The weal and woe of costimulation

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S80. Prolongation of T cell response by OX40 co-signalling CARS

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A dual chain chimeric antigen receptor

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Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas

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T cells redirected by a CD3[zeta] chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term

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T cells redirected by a CD3θ chimeric antigen receptor can establish self-antigen-specific tumour protection in the long term

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Adoptive immunotherapy with genetically engineered T cells: modification of the IgG 1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and un...

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Short DNA Sequences from the Cytoplasm of Mouse Tumor Cells Induce Immortalization of Human Lymphocytes in vitro

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Costimulation tunes tumor-specific activation of redirected T cells in adoptive immunotherapy

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Genetic engineering of human CD4+ CD25+ regulatory T cells with pre-defined target specificity

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Redirecting human CD4 super(+)CD25 super(+) regulatory T cells from the peripheral blood with pre-defined target specificity

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Redirecting human [CD4.sup.+][CD25.sup.+] regulatory T cells from the peripheral blood with pre-defined target specificity

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