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ArticlesPeer ReviewedFull Text
Phenotypic drug discovery: recent successes, lessons learned and new directions
Author / Creator:Vincent, Fabien ; Nueda, Arsenio ; Lee, Jonathan ; Schenone, Monica ; Prunotto, Marco ; Mercola, Mark
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2022-12, Vol.21 (12), p.899-914
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Organs-on-chips: into the next decade
Author / Creator:Low, Lucie A. ; Mummery, Christine ; Berridge, Brian R. ; Austin, Christopher P. ; Tagle, Danilo A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2021-05, Vol.20 (5), p.345-361
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Zebrafish as tools for drug discovery
Author / Creator:MacRae, Calum A. ; Peterson, Randall T.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2015-10, Vol.14 (10), p.721-731
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Image-based profiling for drug discovery: due for a machine-learning upgrade?
Author / Creator:Chandrasekaran, Srinivas Niranj ; Ceulemans, Hugo ; Boyd, Justin D. ; Carpenter, Anne E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2021-02, Vol.20 (2), p.145-159
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Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes
Author / Creator:Bray, Mark-Anthony ; Singh, Shantanu ; Han, Han ; Davis, Chadwick T ; Borgeson, Blake ; Hartland, Cathy ; Kost-Alimova, Maria ; Gustafsdottir, Sigrun M ; Gibson, Christopher C ; Carpenter, Anne E
Publisher:London: Nature Publishing Group UK
Journal title:Nature protocols, 2016-09, Vol.11 (9), p.1757-1774
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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
Author / Creator:Hendriks, Delilah ; Brouwers, Jos F. ; Hamer, Karien ; Geurts, Maarten H. ; Luciana, Léa ; Massalini, Simone ; López-Iglesias, Carmen ; Peters, Peter J. ; Rodríguez-Colman, Maria J. ; Chuva de Sousa Lopes, Susana ; Artegiani, Benedetta ; Clevers, Hans
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2023-11, Vol.41 (11), p.1567-1581
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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic
Author / Creator:Shapira, Tirosh ; Monreal, I. Abrrey ; Dion, Sébastien P. ; Buchholz, David W. ; Imbiakha, Brian ; Olmstead, Andrea D. ; Jager, Mason ; Désilets, Antoine ; Gao, Guang ; Martins, Mathias ; Vandal, Thierry ; Thompson, Connor A. H. ; Chin, Aaleigha ; Rees, William D. ; Steiner, Theodore ; Nabi, Ivan Robert ; Marsault, Eric ; Sahler, Julie ; Diel, Diego G. ; Van de Walle, Gerlinde R. ; August, Avery ; Whittaker, Gary R. ; Boudreault, Pierre-Luc ; Leduc, Richard ; Aguilar, Hector C. ; Jean, François
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2022-05, Vol.605 (7909), p.340-348
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ArticlesPeer ReviewedFull Text
Exercise mimetics: harnessing the therapeutic effects of physical activity
Author / Creator:Gubert, Carolina ; Hannan, Anthony J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2021-11, Vol.20 (11), p.862-879
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Discovery of senolytics using machine learning
Author / Creator:Smer-Barreto, Vanessa ; Quintanilla, Andrea ; Elliott, Richard J. R. ; Dawson, John C. ; Sun, Jiugeng ; Campa, Víctor M. ; Lorente-Macías, Álvaro ; Unciti-Broceta, Asier ; Carragher, Neil O. ; Acosta, Juan Carlos ; Oyarzún, Diego A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2023-06, Vol.14 (1), p.3445-3445, Article 3445
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Phenotypic screening in cancer drug discovery — past, present and future
Author / Creator:Moffat, John G. ; Rudolph, Joachim ; Bailey, David
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2014-08, Vol.13 (8), p.588-602
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Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip
Author / Creator:Nelson, M. Tyler ; Charbonneau, Mark R. ; Coia, Heidi G. ; Castillo, Mary J. ; Holt, Corey ; Greenwood, Eric S. ; Robinson, Peter J. ; Merrill, Elaine A. ; Lubkowicz, David ; Mauzy, Camilla A.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2021-05, Vol.12 (1), p.2805-2805, Article 2805
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ArticlesPeer ReviewedFull Text
Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness
Author / Creator:Khare, Shilpi ; Nagle, Advait S. ; Biggart, Agnes ; Lai, Yin H. ; Liang, Fang ; Davis, Lauren C. ; Barnes, S. Whitney ; Mathison, Casey J. N. ; Myburgh, Elmarie ; Gao, Mu-Yun ; Gillespie, J. Robert ; Liu, Xianzhong ; Tan, Jocelyn L. ; Stinson, Monique ; Rivera, Ianne C. ; Ballard, Jaime ; Yeh, Vince ; Groessl, Todd ; Federe, Glenn ; Koh, Hazel X. Y. ; Venable, John D. ; Bursulaya, Badry ; Shapiro, Michael ; Mishra, Pranab K. ; Spraggon, Glen ; Brock, Ansgar ; Mottram, Jeremy C. ; Buckner, Frederick S. ; Rao, Srinivasa P. S. ; Wen, Ben G. ; Walker, John R. ; Tuntland, Tove ; Molteni, Valentina ; Glynne, Richard J. ; Supek, Frantisek
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2016-09, Vol.537 (7619), p.229-233
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ArticlesPeer ReviewedFull Text
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
Author / Creator:Yu, Channing ; Mannan, Aristotle M ; Yvone, Griselda Metta ; Ross, Kenneth N ; Zhang, Yan-Ling ; Marton, Melissa A ; Taylor, Bradley R ; Crenshaw, Andrew ; Gould, Joshua Z ; Tamayo, Pablo ; Weir, Barbara A ; Tsherniak, Aviad ; Wong, Bang ; Garraway, Levi A ; Shamji, Alykhan F ; Palmer, Michelle A ; Foley, Michael A ; Winckler, Wendy ; Schreiber, Stuart L ; Kung, Andrew L ; Golub, Todd R
Publisher:New York: Nature Publishing Group US
Journal title:Nature biotechnology, 2016-04, Vol.34 (4), p.419-423
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ArticlesPeer ReviewedFull Text
Learning representations for image-based profiling of perturbations
Author / Creator:Moshkov, Nikita ; Bornholdt, Michael ; Benoit, Santiago ; Smith, Matthew ; McQuin, Claire ; Goodman, Allen ; Senft, Rebecca A. ; Han, Yu ; Babadi, Mehrtash ; Horvath, Peter ; Cimini, Beth A. ; Carpenter, Anne E. ; Singh, Shantanu ; Caicedo, Juan C.
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2024-02, Vol.15 (1), p.1594-17, Article 1594
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Applications of chemogenomic library screening in drug discovery
Author / Creator:Jones, Lyn H. ; Bunnage, Mark E.
Publisher:London: Nature Publishing Group UK
Journal title:Nature reviews. Drug discovery, 2017-04, Vol.16 (4), p.285-296
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Selective control of parasitic nematodes using bioactivated nematicides
Author / Creator:Burns, Andrew R. ; Baker, Rachel J. ; Kitner, Megan ; Knox, Jessica ; Cooke, Brittany ; Volpatti, Jonathan R. ; Vaidya, Aditya S. ; Puumala, Emily ; Palmeira, Bruna M. ; Redman, Elizabeth M. ; Snider, Jamie ; Marwah, Sagar ; Chung, Sai W. ; MacDonald, Margaret H. ; Tiefenbach, Jens ; Hu, Chun ; Xiao, Qi ; Finney, Constance A. M. ; Krause, Henry M. ; MacParland, Sonya A. ; Stagljar, Igor ; Gilleard, John S. ; Cowen, Leah E. ; Meyer, Susan L. F. ; Cutler, Sean R. ; Dowling, James J. ; Lautens, Mark ; Zasada, Inga ; Roy, Peter J.
Publisher:London: Nature Publishing Group UK
Journal title:Nature (London), 2023-06, Vol.618 (7963), p.102-109
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Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors
Author / Creator:Steinhart, Zachary ; Pavlovic, Zvezdan ; Chandrashekhar, Megha ; Hart, Traver ; Wang, Xiaowei ; Zhang, Xiaoyu ; Robitaille, Mélanie ; Brown, Kevin R ; Jaksani, Sridevi ; Overmeer, René ; Boj, Sylvia F ; Adams, Jarrett ; Pan, James ; Clevers, Hans ; Sidhu, Sachdev ; Moffat, Jason ; Angers, Stéphane
Publisher:New York: Nature Publishing Group US
Journal title:Nature medicine, 2017-01, Vol.23 (1), p.60-68
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The drug-induced phenotypic landscape of colorectal cancer organoids
Author / Creator:Betge, Johannes ; Rindtorff, Niklas ; Sauer, Jan ; Rauscher, Benedikt ; Dingert, Clara ; Gaitantzi, Haristi ; Herweck, Frank ; Srour-Mhanna, Kauthar ; Miersch, Thilo ; Valentini, Erica ; Boonekamp, Kim E. ; Hauber, Veronika ; Gutting, Tobias ; Frank, Larissa ; Belle, Sebastian ; Gaiser, Timo ; Buchholz, Inga ; Jesenofsky, Ralf ; Härtel, Nicolai ; Zhan, Tianzuo ; Fischer, Bernd ; Breitkopf-Heinlein, Katja ; Burgermeister, Elke ; Ebert, Matthias P. ; Boutros, Michael
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2022-06, Vol.13 (1), p.3135-3135, Article 3135
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Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model
Author / Creator:Mondal, Sudip ; Hegarty, Evan ; Martin, Chris ; Gökçe, Sertan Kutal ; Ghorashian, Navid ; Ben-Yakar, Adela
Publisher:London: Nature Publishing Group UK
Journal title:Nature communications, 2016-10, Vol.7 (1), p.13023-13023, Article 13023
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Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds
Author / Creator:Bruni, Giancarlo ; Rennekamp, Andrew J ; Velenich, Andrea ; McCarroll, Matthew ; Gendelev, Leo ; Fertsch, Ethan ; Taylor, Jack ; Lakhani, Parth ; Lensen, Dennis ; Evron, Tama ; Lorello, Paul J ; Huang, Xi-Ping ; Kolczewski, Sabine ; Carey, Galen ; Caldarone, Barbara J ; Prinssen, Eric ; Roth, Bryan L ; Keiser, Michael J ; Peterson, Randall T ; Kokel, David
Publisher:New York: Nature Publishing Group US
Journal title:Nature chemical biology, 2016-07, Vol.12 (7), p.559-566
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Showing 1 to 20 of 324 results

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Phenotypic drug discovery: recent successes, lessons learned and new directions

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Organs-on-chips: into the next decade

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Zebrafish as tools for drug discovery

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Image-based profiling for drug discovery: due for a machine-learning upgrade?

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Cell Painting, a high-content image-based assay for morphological profiling using multiplexed fluorescent dyes

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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis

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A﻿ TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic

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Exercise mimetics: harnessing the therapeutic effects of physical activity

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Discovery of senolytics using machine learning

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Phenotypic screening in cancer drug discovery — past, present and future

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Characterization of an engineered live bacterial therapeutic for the treatment of phenylketonuria in a human gut-on-a-chip

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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness

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High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines

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Learning representations for image-based profiling of perturbations

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Applications of chemogenomic library screening in drug discovery

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Selective control of parasitic nematodes using bioactivated nematicides

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Genome-wide CRISPR screens reveal a Wnt–FZD5 signaling circuit as a druggable vulnerability of RNF43-mutant pancreatic tumors

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The drug-induced phenotypic landscape of colorectal cancer organoids

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Large-scale microfluidics providing high-resolution and high-throughput screening of Caenorhabditis elegans poly-glutamine aggregation model

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Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds

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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic